蜂王浆对雄性大鼠海马银纳米粒子诱导变化的保护和调节作用

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Mahsa Dalfardi, M. Taghavi, M. S. Kohbanani, Z. Taghipour, Reza Nosratabadi, Reza Nosratabadi, C. Jalili, M. Salahshoor, A. Kaeidi, A. Shabanizadeh
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引用次数: 5

摘要

目的:银纳米粒子由于其重要的性质,包括抗菌和抗氧化应激作用,引起了人们的广泛关注。然而,据报道,高浓度的银纳米粒子具有毒性作用。本研究旨在评估蜂王浆(RJ)对银纳米粒子对海马功能(如学习和记忆)的有害影响的调节和保护作用。材料与方法:本实验在40只雄性Wistar大鼠身上进行。将动物分为四组,每组10只,包括对照组(无银NP和RJ)、RJ组、银NP加RJ和银NP。连续四天使用Morris记忆功能测试评估海马体的一些功能(如学习和记忆)。此外,使用实时聚合酶链式反应(RT-PCR)评估TRPV1的相对表达。在最后阶段,收集海马组织进行组织学研究。结果:与RJ组相比,接受银NPs组的学习和记忆水平、TRPV1的相对基因表达率以及海马的组织学变化有显著差异。结论:根据研究结果,RJ可能对银纳米粒子的不良反应具有有效的保护作用,并能改善海马的功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Protective and modulatory effects of royal jelly used against the induced changes in silver nanoparticles on the hippocampus of male rats
Objective (s): Silver nanoparticles (NPs) have attracted considerable attention owing to their important properties, including antimicrobial and anti-oxidative stress effects. However, high concentrations of silver NPs have been reported to have toxic effects. The present study aimed to evaluate the modulatory and protective effects of royal jelly (RJ) against the harmful effects of silver NPs on hippocampal functions, such as learning and memory. Materials and Methods: This experimental study was conducted on 40 male Wistar rats. The animals were divided into four groups of 10, including the control group (no silver NPs and RJ), RJ group, silver NPs plus RJ, and silver NPs. Some functions of the hippocampus (e.g., learning and memory) were evaluated using Morris memory function tests for four consecutive days. In addition, the relative expression of TRPV1 was assessed using real-time polymerase chain reaction (RT-PCR). At the final stage, hippocampal tissues were collected for histological studies.Results: Levels of learning and memory, relative gene expression ratio of TRPV1, and the histological changes in the hippocampus were significantly different in the groups receiving silver NPs compared to the groups administered with RJ. Conclusion: According to the results, RJ may be the effective in the protection against the adverse effects of silver NPs and improve the function of the hippocampus.
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
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审稿时长
12 weeks
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