淋巴瘤患者自体造血干细胞移植调理方案的研究进展

国际输血及血液学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.06.009

Yueyang Li, Su Liu

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引用次数: 0

摘要

淋巴瘤是一种高度异质性的恶性肿瘤。单纯的化学放射治疗对高度侵袭性淋巴瘤不够有效。自体造血干细胞移植（auto-HSCT）在浸润性淋巴瘤患者的一线治疗中发挥着重要作用，可以提高此类患者的疗效。常见的条件治疗方案是在自体造血干细胞移植前对淋巴瘤患者进行大剂量化疗，包括或不包括全身照射（TBI）。由于并发症和患者耐受性差，这些调理方案的临床应用受到限制。因此，在上述方案的基础上出现的各种改良调理方案以及靶向药物的参与是当前研究的热点。本文综述自体造血干细胞移植治疗淋巴瘤的疗效、毒副反应及研究进展。关键词：淋巴瘤；移植条件；自体移植；造血干细胞移植；分子靶向治疗

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Reasearch progress of conditioning regimens for autologous hematopoietic stem cell transplantation in patients with lymphoma

Lymphoma is a malignant tumor with high heterogeneity. Chemoradiotherapy alone is not sufficiently effective for highly invasive lymphomas. Autologous hematopoietic stem cell transplantation(auto-HSCT) plays an important role in the first-line treatment of patients with invasive lymphomas, which can improve the the efficacy of such patients.The common conditioning regimens are high-dose chemotherapy with or without total body irradiation(TBI) in lymphoma patient before auto-HSCT. The clinical usage of these conditioning regimens were limited due to the complications and poor patient tolerance.Therefore, various improved conditioning regimens emerged based on above regimens and the participation of targeted drugs are hot topics in current research.This article summarize the efficacy, toxicity and research advances of conditioning regimens for auto-HSCT in lymphoma. Key words: Lymphoma; Transplantation conditioning; Transplantation, autologous; Hematopoietic stem cell transplantation; Molecular targeted therapy

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来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.