肝内胆管癌的精确治疗

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2020-02-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2020.02.016

Xiao Liang, L. Tao

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引用次数: 0

摘要

虽然手术切除是目前公认的唯一有效治疗肝内胆管癌(ICC)的方法，但由于早期无明显临床症状，其诊断难度极大。患者通常在晚期诊断，病变不能切除，导致有限的全身化疗。所以死亡率仍然很高。精准治疗是医学领域的热门话题，提高患者的治疗水平越来越受到人们的重视。本文综述了ICC患者的手术治疗、化疗、分子靶向治疗和免疫治疗等相关问题，并重点介绍了分子靶向治疗的最新进展。关键词:胆管肿瘤;肝内胆管癌;精确的治疗;分子靶向治疗

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Precise treatment of intrahepatic cholangiocarcinoma

Although surgical resection is currently recognized as the only effective treatment for intrahepatic cholangiocarcinoma (ICC), it is extremely difficult to diagnose because there are no obvious clinical symptoms at the early stage. Patients are often diagnosed at the advanced stage and the lesion cannot be resected which leads to limited systemic chemotherapy. So the mortality is still high. Accurate treatment is a hot topic in the medical field, and more and more attentions have been paid to enhance the treatments of patients. This article reviewed the issues related to surgical treatment, chemotherapy, molecular targeted therapy, and immunotherapy in patients with ICC, and focuses on the latest progress of molecular targeted therapy. Key words: Bile duct neoplasms; Intrahepatic cholangiocarcinoma; Precise treatment; Molecular targeted therapy

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.