n -乙酰半胱氨酸在肺矽肺中的治疗潜力是什么?

Acta Medica Martiniana Pub Date : 2021-12-01 DOI:10.2478/acm-2021-0011

A. Jana, M. Daniela

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引用次数: 0

摘要

肺矽肺病是由肺部吸入二氧化硅(SiO2)或二氧化硅引起的严重肺部疾病。虽然该病的病理机制尚未完全阐明，但氧化应激已被认为是引发纤维化炎症的基本因素，导致肺组织发生不可逆的变化。基于这一认识，各种抗氧化剂的治疗潜力得到了深入的讨论。其中，n -乙酰半胱氨酸具有多种抗炎和抗氧化作用，在临床治疗多种疾病方面有着长期的应用经验，是一个很有前景的选择。本文旨在综述n -乙酰半胱氨酸在肺损伤中的治疗作用，并指出n -乙酰半胱氨酸在肺矽肺治疗中的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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What is a Therapeutic Potential of N-Acetylcysteine in Lung Silicosis?

Abstract Lung silicosis is a serious pulmonary disease caused by an exposure of lung to inhaled silicon dioxide (SiO2) or silica. Although pathomechanisms of the disease have not been fully elucidated, oxidative stress has been recognized as a fundamental factor triggering a fibrotizing inflammation leading to irreversible changes in lung tissue. Based on this knowledge, therapeutic potential of various antioxidants has been intensively discussed. Among them, N-acetylcysteine with its multiple anti-inflammatory and antioxidant actions and a long-term experience with its clinical use in various diseases appears as a very promising choice. The purpose of this article is to review the therapeutic effects of N-acetylcysteine particularly in relation to a lung injury and to point out a potential of N-acetylcysteine in the treatment of lung silicosis.

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来源期刊

Acta Medica Martiniana

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.