长双歧杆菌亚种在母乳喂养婴儿中的定植。婴儿EVC001降低毒力基因丰度

Q1 Medicine

Human Microbiome Journal Pub Date : 2018-08-01 DOI:10.1016/j.humic.2018.05.001

Giorgio Casaburi , Steven A. Frese

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引用次数: 30

摘要

婴儿肠道微生物群在出生后迅速被环境中的细菌定植，这种肠道生态系统可以促进潜在病原体的扩张。母乳塑造了婴儿肠道微生物群，并已进化到促进特定细菌的生长。母乳喂养的婴儿喂养共同进化的婴儿肠道共生体长双歧杆菌亚种。婴儿EVC001对他们的肠道宏基因组有显著的改变，包括毒力因子基因的数量减少。

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Colonization of breastfed infants by Bifidobacterium longum subsp. infantis EVC001 reduces virulence gene abundance

The infant gut microbiome is rapidly colonized by bacteria from the environment after birth, and this gut ecosystem can facilitate expansion of potential pathogens. Human milk shapes the infant gut microbiome and has evolved to foster the growth of specific bacteria. Breastfed infants fed the coevolved infant gut symbiont Bifidobacterium longum subsp. infantis EVC001 had significant modifications to their gut metagenome, including a decreased number of virulence factor genes.

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来源期刊

Human Microbiome Journal Medicine-Infectious Diseases

自引率

0.00%

发文量

期刊介绍： The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.