Marianna Tavares Venceslau, Giuliana Pucarelli Lebreiro, Gabrielly de Souza Leitão, Brenda Klemm Arci Mattos de Freitas Alves, Luane Abdalla Gouvea, Giuseppe Mario Carmine Pastura, Thiago Dias Anachoreta, Regina Cláudia Silva da Rocha, Fernanda Queiroz Maciel, Catherine Crespo Cordeiro, Terezinha Marta Pereira Pinto Castiñeiras, Thalita Fernandes Abreu, Ana Cristina Cisne Frota, Rafael Brandão Varella, Maria Angelica Arpon Marandino Guimarães, Cristina Barroso Hofer
{"title":"与儿童SARS-CoV-2相关的神经系统表现:一个病例系列","authors":"Marianna Tavares Venceslau, Giuliana Pucarelli Lebreiro, Gabrielly de Souza Leitão, Brenda Klemm Arci Mattos de Freitas Alves, Luane Abdalla Gouvea, Giuseppe Mario Carmine Pastura, Thiago Dias Anachoreta, Regina Cláudia Silva da Rocha, Fernanda Queiroz Maciel, Catherine Crespo Cordeiro, Terezinha Marta Pereira Pinto Castiñeiras, Thalita Fernandes Abreu, Ana Cristina Cisne Frota, Rafael Brandão Varella, Maria Angelica Arpon Marandino Guimarães, Cristina Barroso Hofer","doi":"10.1177/11795735221102740","DOIUrl":null,"url":null,"abstract":"<p><p>Neurological manifestations of COVID-19 may affect both central and peripheral nervous systems. Unlike in adults, in whom majority of severe cases derive from respiratory complications, neurological involvement is one of the main causes of severe COVID-19 in children. This study aimed to detect viral respiratory pathogens, mainly SARS-CoV-2, in nasopharynx and cerebrospinal fluid samples utilizing qRT-PCR (TaqMan) in a pediatric population in Brazil. We evaluated four children with neurological symptoms and laboratory-confirmed SARS-CoV-2 infection: three presenting with meningoencephalitis and one presenting with Guillain-Barré syndrome. All four patients had mild respiratory symptoms. SARS-CoV-2 RNA was identified in two cerebrospinal fluid samples. SARS-CoV-2 involvement should be considered for differential diagnosis in pediatric cases presenting neurological alterations even if symptoms such as headache, anosmia, or dizziness are absent.</p>","PeriodicalId":15218,"journal":{"name":"Journal of Central Nervous System Disease","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2022-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131375/pdf/","citationCount":"4","resultStr":"{\"title\":\"Neurological Manifestations Associated With SARS-CoV-2 in Children: A Case Series.\",\"authors\":\"Marianna Tavares Venceslau, Giuliana Pucarelli Lebreiro, Gabrielly de Souza Leitão, Brenda Klemm Arci Mattos de Freitas Alves, Luane Abdalla Gouvea, Giuseppe Mario Carmine Pastura, Thiago Dias Anachoreta, Regina Cláudia Silva da Rocha, Fernanda Queiroz Maciel, Catherine Crespo Cordeiro, Terezinha Marta Pereira Pinto Castiñeiras, Thalita Fernandes Abreu, Ana Cristina Cisne Frota, Rafael Brandão Varella, Maria Angelica Arpon Marandino Guimarães, Cristina Barroso Hofer\",\"doi\":\"10.1177/11795735221102740\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Neurological manifestations of COVID-19 may affect both central and peripheral nervous systems. Unlike in adults, in whom majority of severe cases derive from respiratory complications, neurological involvement is one of the main causes of severe COVID-19 in children. This study aimed to detect viral respiratory pathogens, mainly SARS-CoV-2, in nasopharynx and cerebrospinal fluid samples utilizing qRT-PCR (TaqMan) in a pediatric population in Brazil. We evaluated four children with neurological symptoms and laboratory-confirmed SARS-CoV-2 infection: three presenting with meningoencephalitis and one presenting with Guillain-Barré syndrome. All four patients had mild respiratory symptoms. SARS-CoV-2 RNA was identified in two cerebrospinal fluid samples. SARS-CoV-2 involvement should be considered for differential diagnosis in pediatric cases presenting neurological alterations even if symptoms such as headache, anosmia, or dizziness are absent.</p>\",\"PeriodicalId\":15218,\"journal\":{\"name\":\"Journal of Central Nervous System Disease\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2022-05-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9131375/pdf/\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Central Nervous System Disease\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/11795735221102740\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Central Nervous System Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/11795735221102740","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Neurological Manifestations Associated With SARS-CoV-2 in Children: A Case Series.
Neurological manifestations of COVID-19 may affect both central and peripheral nervous systems. Unlike in adults, in whom majority of severe cases derive from respiratory complications, neurological involvement is one of the main causes of severe COVID-19 in children. This study aimed to detect viral respiratory pathogens, mainly SARS-CoV-2, in nasopharynx and cerebrospinal fluid samples utilizing qRT-PCR (TaqMan) in a pediatric population in Brazil. We evaluated four children with neurological symptoms and laboratory-confirmed SARS-CoV-2 infection: three presenting with meningoencephalitis and one presenting with Guillain-Barré syndrome. All four patients had mild respiratory symptoms. SARS-CoV-2 RNA was identified in two cerebrospinal fluid samples. SARS-CoV-2 involvement should be considered for differential diagnosis in pediatric cases presenting neurological alterations even if symptoms such as headache, anosmia, or dizziness are absent.
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