早期重度子痫前期胎盘组织中TNF-α和M-CSF的表达及意义

中国综合临床 Pub Date : 2019-07-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2019.04.018

Hongling Wang, Guo-liang Liu, Jiaojiao Zhou

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引用次数: 0

摘要

目的探讨巨噬细胞集落刺激因子（M-CSF）和肿瘤坏死因子α（TNF-α）在早发重度子痫前期（PE）胎盘中的表达及其临床意义。方法采用免疫组织化学SP法检测河南科技大学第一附属医院病理科2015年9月至2017年9月77例石蜡标本中M-CSF和TNF-α的表达，其中早发性重度PE 35例，晚发性重度PE 42例，正常孕妇30例。结果（1）M-CSF在对照组、晚发型重度PE组和早发性重度PE组的阳性表达率分别为30%（9/30）、61.90%（26/42）和82.86%（29/35）。差异有统计学意义（χ2=18.90，P<0.05）。早发性重度PE组的阳性表达率显著高于对照组（χ2=18.59，P<0.05），差异具有统计学意义。。早发性重度PE组的TNF-α阳性表达率高于晚发性重度聚乙烯组，差异有统计学意义（χ2=4.017，P<0.05）。（2）对照组、晚发性重型PE组和早发性重型聚乙烯组TNF-α的阳性表达率分别为33.33%（10/30）、69.05%（29/42）和91.43%（32/35）。差异有统计学意义（χ2=30.21，P<0.05）。早发性重度PE组TNF-α的阳性表达显著高于对照组（χ2=21.37，P<0.05），差异具有统计学意义。M-CSF和TNF-a在早发性重度PE组的阳性表达高于晚发性重症PE组，差异有统计学意义（χ2=4.529，P<0.05）；（3） M-CSF和TNF-α在PE中的表达呈正相关（r=0.441，P=0.000）。PE患者胎盘中M-CSF和TNF-α水平可能在PE的发生和发展中起协同作用；早期发病的重度子痫前期；胎盘组织；巨噬细胞集落刺激因子；肿瘤坏死因子α

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Expression and significance of TNF-α and M-CSF in placenta tissue of early severe preeclampsia

Objective To investigate the expression and clinical significance of macrophage colony stimulating factor (M-CSF) and tumor necrosis factor α (TNF-α) in placenta of early onset severe preeclampsia (PE). Methods Immunohistochemical SP method was used to detect the expression of M-CSF and TNF-α in 77 cases paraffin specimens from Department of Pathology, First Affiliated Hospital of Henan University of Science and Technology from September 2015 to September 2017, including 35 cases of early-onset severe PE, 42 cases of late-onset severe PE and 30 cases of normal pregnant women. Results (1)The positive expression rates of M-CSF in control group, late-onset severe PE group and early-onset severe PE group were 30% (9/30), 61.90% (26/42), 82.86% (29/35), respectively.The difference was statistically significant (χ2=18.90, P<0.05). The positive expression rates of early-onset severe PE group were significantly higher than those in control group (χ2=18.59, P<0.05), and the difference was statistically significant..The positive expression of early-onset severe PE group was higher than that of late-onset severe PE group, and the difference was statistically significant (χ2=4.017, P<0.05). (2) The positive expression rates of TNF-α in control group, late-onset severe PE group and early-onset severe PE group were 33.33% (10/30), 69.05% (29/42), 91.43% (32/35), respectively.The difference was statistically significant (χ2=30.21, P<0.05). The positive expression of TNF-α in early-onset severe PE group was significantly higher than that in control group (χ2=21.37, P<0.05), and the difference was statistically significant.The positive expression of M-CSF and TNF-a in early-onset severe PE group was higher than that in late-onset severe PE group, and the difference was statistically significant (χ2=4.529, P<0.05); (3) The expression of M-CSF and TNF-α was positively correlated in PE (r=0.441, P=0.000). Conclusion Placental damage is higher in early-onset severe PE, and is related to the severity of the disease.The levels of M-CSF and TNF-alpha in placenta of PE patients may play a synergistic role in the occurrence and development of PE. Key words: Preeclampsia; Early onset severe preeclampsia; Placental tissue; Macrophage colony-stimulating factor; Tumor necrosis factor α

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来源期刊

中国综合临床

CiteScore

0.10

自引率

0.00%

发文量

16855

期刊介绍： Clinical Medicine of China is an academic journal organized by the Chinese Medical Association (CMA), which mainly publishes original research papers, reviews and commentaries in the field. Clinical Medicine of China is a source journal of Peking University (2000 and 2004 editions), a core journal of Chinese science and technology, an academic journal of RCCSE China Core (Extended Edition), and has been published in Chemical Abstracts of the United States (CA), Abstracts Journal of Russia (AJ), Chinese Core Journals (Selection) Database, Chinese Science and Technology Materials Directory, Wanfang Database, China Academic Journal Database, JST Japan Science and Technology Agency Database (Japanese) (2018) and other databases.