Epidemic Process Manifestations and Leading Factors of Transmission of The Pathogenes of the Enterovirus Infection Basic Clinical Forms

Relevance .The urgency of the problem of non-polio enterovirus infection is determined by the wide spread of pathogens, the occurrence of outbreak of morbidity, polymorphism of clinical manifestations and the lack of specific prophylaxis. Most often non-polio enterovirus infection is asymptomatic. Clinically expressed  forms can be serous meningitis, herpetic sore throat, eczematous fever, vesicular pharyngitis, gastroenteritis,  epidemic myalgia (pleurodynia), tonsillitis, myocarditis, pericarditis, hemorrhagic conjunctivitis, uveitis, etc. The aim of the work is a comparative evaluation of the epidemic process  manifestations and the leading factors of serous meningitis (SM)  pathogens,  enterovirus  etiology herpetic angina  (HA) transmission  and enterovirus  etiology gastroenteritis  (GE). Materials  and  methods . Manifestations of the epidemic process of SM and HA were studied according to the official registration of the incidence of the population of Perm for the 2010–2017.  In conditions of analytical «case-control»  method the epidemiological survey of 350 epidemiological focuses of SM and 142 focuses of HA and 61 focuses of GE were conducted.  Results . According to official registration data, the incidence rates of NEVI in the population of Perm during the last 7 years (2010–2017) ranged from 0.3 to 21.5, averaging 5.4 per 100 thousand population. There were mainly three clinical forms registered - serous meningitis, herpetic sore throat, gastroenteritis, the proportion of which was 45.3; 36.6 and 12.4%, respectively. The findings clearly demonstrate that it is similarity between epidemic process manifestations of SM, HA and enterovirus etiology gastroenteritis. Conclusion . In both clinical variants of enterovirus infection the priority role is the water way of transmission of the pathogen by drinking water from centralized and decentralized sources of water system, as well as swimming in surface water.