添加剂调制立体选择性糖苷化反应的新进展

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2021-01-01 DOI:10.1080/07328303.2022.2027432

Miaomiao Zhang , Tianlu Li , Peng Peng

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引用次数: 1

摘要

立体选择性糖苷键形成(称为糖苷化)仍然是碳水化合物化学中的一个挑战。尽管困难重重，但各种创新策略已被开发出来。特别是加成调制的立体选择结构的糖苷键已成为一个新兴的趋势。在这篇综述中，我们总结了近年来在这一领域的研究进展，包括常见的糖基供体，包括硫糖苷类、糖基酰肟类、糖基酰乙酸类、糖基半缩醛类、糖基磷酸类和糖基正炔基苯甲酸酯类。结合它们的优点和局限性，这些成果揭示了碳水化合物化学，并使复杂低聚糖和糖缀合物的有效制备成为可能。

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Recent development in additive modulated stereoselective glycosidation reactions

Stereoselective glycosidic bond formation (termed “glycosidation”) remains a challenge in carbohydrate chemistry. Despite such difficulty, a variety of innovative strategies have been developed. In particular, additive-modulated stereoselective construction of glycosidic linkages has become an emerging trend. In this review, we summarized the recent progress in this area with respect to common glycosyl donors, including thioglycosides, glycosyl imidates, glycosyl acetates, glycosyl hemiacetals, glycosyl phosphates and glycosyl ortho-alkynylbenzoates. Together with their merits/limitations, these achievements shed light on carbohydrate chemistry and enabled the efficient preparation of complex oligosaccharides and glycoconjugates.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.