正电子素应用于血栓结构特征的可行性研究

IF 1.2 Q3 Computer Science

Bio-Algorithms and Med-Systems Pub Date : 2022-12-01 DOI:10.2478/bioal-2022-0087

S. Moyo, P. Moskal, E. Stępień

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引用次数: 1

摘要

生物体中约30%的正电子电子湮灭是通过亚稳态邻位正电子原子的形成而发生的，由于拾取和转换过程，该原子在组织中湮灭为两个511keV的光子。正电子（Ps）湮灭寿命和强度可用于确定材料微观结构中缺陷的大小和数量，例如纳米范围内的空隙或孔隙。血栓尤其如此。在此，我们对纤维蛋白凝块中的正电子素特性进行了初步研究。这些研究通过使用SEM Edax和微型计算机断层扫描（µCT）来评估提取的血栓材料的性质。µCT是一种多功能的表征方法，提供了原位和操作的可能性，是一种定性诊断工具。使用µCT可以验证孔隙、裂纹和结构误差的存在，因此可以研究样品的3D内部结构。

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Feasibility study of positronium application for blood clots structural characteristics

Positron-electron annihilation in living organisms occurs in about 30% via the formation of a metastable ortho-positronium atom that annihilates into two 511 keV photons in tissues because of the pick-off and conversion processes. Positronium (Ps) annihilation lifetime and intensities can be used to determine the size and quantity of defects in a material’s microstructure, such as voids or pores in the range of nanometers. This is particularly true for blood clots. Here we present pilot investigations of positronium properties in fibrin clots. The studies are complemented by the use of SEM Edax and micro-computed tomography (µCT) to evaluate the extracted thrombotic material’s properties. µCT is a versatile characterization method offering in situ and in operando possibilities and is a qualitative diagnostic tool. With µCT the presence of pores, cracks, and structural errors can be verified, and hence the 3D inner structure of samples can be investigated.

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来源期刊

Bio-Algorithms and Med-Systems MATHEMATICAL & COMPUTATIONAL BIOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

期刊介绍： The journal Bio-Algorithms and Med-Systems (BAMS), edited by the Jagiellonian University Medical College, provides a forum for the exchange of information in the interdisciplinary fields of computational methods applied in medicine, presenting new algorithms and databases that allows the progress in collaborations between medicine, informatics, physics, and biochemistry. Projects linking specialists representing these disciplines are welcome to be published in this Journal. Articles in BAMS are published in English. Topics Bioinformatics Systems biology Telemedicine E-Learning in Medicine Patient''s electronic record Image processing Medical databases.