{"title":"微小RNA-221/222簇是否预示着心血管疾病的新时代？","authors":"Lutfu Askin, Okan Tanriverdi","doi":"10.33678/cor.2022.050","DOIUrl":null,"url":null,"abstract":"In addition to regulating gene expression, microRNAs (MiRs) regulate messenger RNA degradation and translation rates. MiRs have a high expression in the cardiovascular (CV) system, indicating an important role in vascular health. The atherosclerotic process has been related to miRs-221 and -222. MiRs-221/222 possess anti-stenotic activity. MiR-221/222 may potentially serve as a marker for myocardial remodeling. There is still a long way yet before miRs-221/222 can be recognized as a potential therapeutic target. Identifi cation, validation, and understanding of the function of gene targets are all critical. Klíčová slova: Kardiovaskulární systém MikroRNA MiR-221/222 Působení proti tvorbě stenóz Remodelace","PeriodicalId":10787,"journal":{"name":"Cor et vasa","volume":" ","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases?\",\"authors\":\"Lutfu Askin, Okan Tanriverdi\",\"doi\":\"10.33678/cor.2022.050\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In addition to regulating gene expression, microRNAs (MiRs) regulate messenger RNA degradation and translation rates. MiRs have a high expression in the cardiovascular (CV) system, indicating an important role in vascular health. The atherosclerotic process has been related to miRs-221 and -222. MiRs-221/222 possess anti-stenotic activity. MiR-221/222 may potentially serve as a marker for myocardial remodeling. There is still a long way yet before miRs-221/222 can be recognized as a potential therapeutic target. Identifi cation, validation, and understanding of the function of gene targets are all critical. Klíčová slova: Kardiovaskulární systém MikroRNA MiR-221/222 Působení proti tvorbě stenóz Remodelace\",\"PeriodicalId\":10787,\"journal\":{\"name\":\"Cor et vasa\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cor et vasa\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.33678/cor.2022.050\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cor et vasa","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.33678/cor.2022.050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Is the microRNA-221/222 Cluster Ushering in a New Age of Cardiovascular Diseases?
In addition to regulating gene expression, microRNAs (MiRs) regulate messenger RNA degradation and translation rates. MiRs have a high expression in the cardiovascular (CV) system, indicating an important role in vascular health. The atherosclerotic process has been related to miRs-221 and -222. MiRs-221/222 possess anti-stenotic activity. MiR-221/222 may potentially serve as a marker for myocardial remodeling. There is still a long way yet before miRs-221/222 can be recognized as a potential therapeutic target. Identifi cation, validation, and understanding of the function of gene targets are all critical. Klíčová slova: Kardiovaskulární systém MikroRNA MiR-221/222 Působení proti tvorbě stenóz Remodelace
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