龙葵醇提物的治疗作用。多囊卵巢综合征雌性大鼠模型

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
R. Tahvilian, M. Gravandi, T. Noori, A. Papzan, Nasim Jamshidi, Amin Iranpanah, Afsaneh Moradi, S. Shirooie
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引用次数: 1

摘要

目的:多囊卵巢综合征(PCOS)是最常见的内分泌疾病之一,影响5%-10%的育龄妇女。一些因素有助于多囊卵巢综合征的发展,如下丘脑-垂体轴功能障碍和卵巢功能,以及胰岛素水平升高。该疾病的表现包括广泛的症状,包括月经失调、痤疮、不孕不育和体脂增加。目前,多囊卵巢综合征最著名的治疗方法是克罗米芬、二甲双胍、来曲唑和他莫昔芬。由于其副作用,识别替代药物至关重要。通常在世界不同地区使用的传统药物之一,特别是在西欧,是dioica Bryonia Jacq。(B.dioica)。这种植物因其多酚等活性成分而被用于治疗疾病。材料和方法:通过皮下注射对映酸睾酮(1 mg/100g),连续35天。B.dioica的影响(30和60 mg/kg)根甲醇提取物对PCOS诱导的PCOS的影响。最后一天,测量血清促卵泡激素(FSH)、葡萄糖、低密度脂蛋白/高密度脂蛋白(LDL/HDL)、促黄体生成素(LH)和睾酮水平,并进行组织学研究(苏木精和伊红[H&E]染色)。结果:与PCOS组相比,dioica组的FSH和LH水平(P<0.05)以及葡萄糖水平(P<0.001)显著正常。在所有治疗组中,大鼠的LDL水平降低并且LDL/HDL比率降低。在组织学分析中,二甲双胍和B.dioica限制了睾酮对大鼠卵巢的影响。结论:数据表明,dioica甲醇提取物可恢复PCOS中的激素因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The therapeutic effect of methanolic extract Bryonia dioica Jacq. in a female rat model of polycystic ovary syndrome
Objective: Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases that affects 5%–10% of women of childbearing age. Several factors contribute to the development of PCOS such as dysfunction of the hypothalamic–pituitary axis and ovarian function, as well as increased insulin levels. The manifestations of the disorder include a wide range of symptoms, including menstrual disorders, acne, infertility, and increased body fat. Currently, the most well-known treatments for PCOS are clomiphene, metformin, letrozole, and tamoxifen. Due to their side effects, the identification of substitute drugs is essential. One of the traditional medicines, which is usually used in different parts of the world, particularly in Western Europe, is Bryonia dioica Jacq. (B. dioica). This plant is used in the treatment of disease due to its active ingredients like polyphenols. Materials and Methods: Induction PCOS in a female rat (3 weeks old) was performed through subcutaneous injection of testosterone enanthate (1 mg/100g) daily for 35 days. The effects of B. dioica (30 and 60 mg/kg) root methanolic extract on PCOS-induced was evaluated after 28-day treatment. On the last day, the serum levels of follicle-stimulating hormone (FSH), glucose, low-density lipoprotein/high-density lipoprotein (LDL/HDL), luteinizing hormone (LH), and testosterone and histological studies (hematoxylin and eosin [H&E] staining) were measured. Results: Results showed that FSH and LH levels (P < 0.05) as well as glucose (P < 0.001) in the B. dioica groups normalized significantly compared to the PCOS group. LDL levels decreased in rats and the LDL/HDL ratio decreased in all treatment groups. In histologic assay, metformin and B. dioica restricted the effects of testosterone in the ovaries of rats. Conclusion: The data indicate that methanolic extract of B. dioica recovers hormonal factors in PCOS.
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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