猪的发声器:聚类在临床试验设计、分析和解释中的重要性

IF 0.7 4区 农林科学 Q3 Agricultural and Biological Sciences
J. Sargeant, A. O'Connor, T. O’Sullivan, A. Ramirez, Chong Wang
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引用次数: 0

摘要

在围栏、房间、谷仓或农场的水平上聚集动物会导致个体猪在统计上的不依赖性。在确定样本量时不考虑聚类将导致临床试验太小,无法在分析中控制聚类时检测到干预组之间的有意义差异。分析中未能控制聚类将导致置信区间不适当地变窄,并增加假阳性发现的概率。因此,在试验设计和分析中没有考虑聚类会导致研究中对干预措施的使用决策产生误导。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A sounder of swine: The importance of clustering in the design, analysis, and interpretation of clinical trials
Clustering of animals at the level of pens, rooms, barns, or farms leads to statistical nonindependence of individual pigs. Failure to consider clustering when determining sample size will result in clinical trials that are too small to detect meaningful differences between intervention groups when clustering is controlled in the analysis. Failure to control clustering in the analysis will lead to inappropriately narrow confidence intervals and increases the probability of a false-positive finding. Thus, failure to consider clustering in trial design and analysis results in research that could misinform decision making on the use of interventions.
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
29
审稿时长
>36 weeks
期刊介绍: The Journal of Swine Health & Production (JSHAP) is an open-access and peer-reviewed journal published by the American Association of Swine Veterinarians (AASV) since 1993. The aim of the journal is the timely publication of peer-reviewed papers with a scope that encompasses the many domains of applied swine health and production, including the diagnosis, treatment, management, prevention and eradication of swine diseases, welfare & behavior, nutrition, public health, epidemiology, food safety, biosecurity, pharmaceuticals, antimicrobial use and resistance, reproduction, growth, systems flow, economics, and facility design. The journal provides a platform for researchers, veterinary practitioners, academics, and students to share their work with an international audience. The journal publishes information that contains an applied and practical focus and presents scientific information that is accessible to the busy veterinary practitioner as well as to the research and academic community. Hence, manuscripts with an applied focus are considered for publication, and the journal publishes original research, brief communications, case reports/series, literature reviews, commentaries, diagnostic notes, production tools, and practice tips. All manuscripts submitted to the Journal of Swine Health & Production are peer-reviewed.
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