用于药物递送应用的粘膜粘附微丸：综述

IF 3.5 Q2 Materials Science

Reviews of Adhesion and Adhesives Pub Date : 2020-06-30 DOI:10.7569/raa.2020.097305

I. Singh, G. Devi, B. Barik, Ankita Sharma, Loveleen Kaur

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引用次数: 11

摘要

微丸是一种球形多颗粒药物递送系统，尺寸在0.5-2.0毫米之间。微丸的一些优点是自由流动、良好的机械性能、改进的粉末物理和化学性能以及稳定性。可以通过使用适当浓度和类型的粘膜粘合剂聚合物来开发粘膜粘合剂颗粒。粘膜粘附颗粒可用于将药物输送到胃、结肠和阴道区域。即时释放、持续/控制释放和植入式递送可以使用粘膜粘合剂颗粒。可重复性、易于扩展、质量控制检查和显著的机械强度是使颗粒被制药行业广泛接受的一些优势。本综述介绍了粘膜粘附过程和理论、粘膜粘附聚合物、造粒过程、微丸的评价以及用于递送不同类别药物的粘膜粘附微丸的研究/专利报告。

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Mucoadhesive Pellets for Drug Delivery Applications: A Critical Review

Pellets are spherical shaped multiparticulate drug delivery systems with size ranging between 0.5-2.0 mm. Free flow, good mechanical properties, improved physical and chemical properties of powder, and stability are some advantages of pellets. Mucoadhesive pellets could be developed by using appropriate concentration and type of mucoadhesive polymer. Mucoadhesive pellets can be used for delivery of drugs to gastric, colonic, and vaginal regions. Immediate release, sustained/controlled release and implantable delivery could be incorporated using mucoadhesive pellets. Reproducibility, ease of scalability, quality control checks and significant mechanical strength are some advantages making pellets widely acceptable by pharmaceutical industry. In the present review, mucoadhesion process and theories, mucoadhesive polymers, pelletization process, evaluation of pellets and reported research/patents on mucoadhesive pellets for delivery of different categories of drugs have been presented.

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来源期刊

Reviews of Adhesion and Adhesives MATERIALS SCIENCE, MULTIDISCIPLINARY-

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期刊介绍： With the explosion of research activity and reports, the need for concise and critical reviews of topics of contemporary research interest is manifest. Reviews of Adhesion and Adhesives (RAA) provides in-depth, incisive, illuminating and thought-provoking reviews written by subject matter experts covering all aspects of adhesion science and adhesive technology. Each review will be imbued with the author’s experience so that the reader will be able to assimilate the research in the area discussed easily and will be able to apply it in practice.The journal has relevance to a myriad of industries including textiles, printing, coatings, aerospace, medical, nanotechnology, biotechnology, building and construction, and microelectronics. The topics to be covered include, but not limited to, basic and theoretical aspects of adhesion; modeling of adhesion phenomena; mecha¬nisms of adhesion; surface and interfacial analysis and characterization; unraveling of events at interfaces; characterization of interphases; adhesion of thin films and coatings; adhesion aspects in reinforced composites; formation, characterization and durability of adhesive joints; surface preparation methods; polymer surface modification; biological adhesion; particle adhesion; adhesion of metallized plastics; adhesion of diamond-like films; adhesion pro¬moters; contact angle, wettability· and adhesion; superhydrophobicity and superhydrophilicity. With regard to adhesives, RAA will include, but not limited to, green adhesives; novel and high-performance adhesives; and medical adhesive applications.