脑卒中、神经变性和老龄化患者脑血管重建的治疗机会和输送策略

IF 19.3 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Idoia Gallego, Ilia Villate-Beitia, L. Saenz-del-Burgo, G. Puras, J. Pedraz
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引用次数: 10

摘要

中枢神经系统(CNS)疾病,特别是急性缺血性事件和神经退行性疾病,构成了一个公共卫生问题,没有有效的治疗方法可以持久解决。针对神经元恢复的失败治疗揭示了缺血性中风、Alzheimeŕs疾病、肌萎缩侧索硬化症、血管性帕金森氏症、血管性痴呆和衰老等中枢神经系统疾病背后的多因素和复杂的病理生理,其中脑微血管损伤似乎起着关键作用。事实上,在这些情况下,血管密度和脑血流量会减少,导致神经元功能障碍,导致认知功能丧失。在这篇综述中,我们概述了健康大脑微血管的结构和功能,以及上述脑中枢神经系统疾病的影响。我们讨论了新兴的新的治疗机会,和他们的交付方法,旨在恢复脑血管在这种情况下。由于缺乏有效的治疗方法,主要集中在神经元恢复上,这促使人们寻找治疗大脑中枢神经系统疾病的其他疗法。脑微血管的破坏和退化在神经退行性疾病、中风和衰老中已得到证实,这是通过发展促血管生成治疗策略来恢复血管化、神经元功能和认知能力的潜在目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Therapeutic Opportunities and Delivery Strategies for Brain Revascularization in Stroke, Neurodegeneration, and Aging
Central nervous system (CNS) diseases, especially acute ischemic events and neurodegenerative disorders, constitute a public health problem with no effective treatments to allow a persistent solution. Failed therapies targeting neuronal recovery have revealed the multifactorial and intricate pathophysiology underlying such CNS disorders as ischemic stroke, Alzheimeŕs disease, amyotrophic lateral sclerosis, vascular Parkisonism, vascular dementia, and aging, in which cerebral microvasculature impairment seems to play a key role. In fact, a reduction in vessel density and cerebral blood flow occurs in these scenarios, contributing to neuronal dysfunction and leading to loss of cognitive function. In this review, we provide an overview of healthy brain microvasculature structure and function in health and the effect of the aforementioned cerebral CNS diseases. We discuss the emerging new therapeutic opportunities, and their delivery approaches, aimed at recovering brain vascularization in this context. Significance Statement The lack of effective treatments, mainly focused on neuron recovery, has prompted the search of other therapies to treat cerebral central nervous system diseases. The disruption and degeneration of cerebral microvasculature has been evidenced in neurodegenerative diseases, stroke, and aging, constituting a potential target for restoring vascularization, neuronal functioning, and cognitive capacities by the development of therapeutic pro-angiogenic strategies.
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来源期刊
Pharmacological Reviews
Pharmacological Reviews 医学-药学
CiteScore
34.70
自引率
0.50%
发文量
40
期刊介绍: Pharmacological Reviews is a highly popular and well-received journal that has a long and rich history of success. It was first published in 1949 and is currently published bimonthly online by the American Society for Pharmacology and Experimental Therapeutics. The journal is indexed or abstracted by various databases, including Biological Abstracts, BIOSIS Previews Database, Biosciences Information Service, Current Contents/Life Sciences, EMBASE/Excerpta Medica, Index Medicus, Index to Scientific Reviews, Medical Documentation Service, Reference Update, Research Alerts, Science Citation Index, and SciSearch. Pharmacological Reviews offers comprehensive reviews of new pharmacological fields and is able to stay up-to-date with published content. Overall, it is highly regarded by scholars.
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