天麻素通过Nrf2信号通路在创伤性脑损伤模型中提供神经保护

IF 4.6 3区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Quality Assurance and Safety of Crops & Foods Pub Date : 2021-12-07 DOI:10.15586/qas.v13i4.965

Dan Wang, Xiaoqing Dong

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引用次数: 1

摘要

天麻素是天麻的主要活性成分之一，对多种神经系统疾病具有重要的治疗价值。其药用特性有平滑肌松弛、抗坏死、抗衰老、抗细胞凋亡等作用。然而，其对创伤性脑损伤(TBI)的可能影响尚不清楚。本研究探讨天麻素对脑外伤大鼠的影响。结果证明天麻素通过减轻脑损伤大鼠脑缺损、降低脑含水量、抑制神经元凋亡、抑制脑组织氧化应激等对TBI具有神经保护作用。天麻素机械上调Nrf2下游蛋白表达，提示Nrf2通路在TBI大鼠脑组织中激活。综上所述，天麻素通过Nrf2通路对TBI大鼠具有神经保护作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Gastrodin provides neuroprotection in models of traumatic brain injury via Nrf2 signaling pathway

Gastrodin is one of the main active components of Gastrodia elata and has significant therapeutic value for various nervous system diseases. Its medicinal properties include smooth muscle relaxation, anti-necrosis, anti-aging, and anti-apoptosis effects. However, its possible effects on traumatic brain injury (TBI) are still unclear. In this study, the effects of gastroditin on TBI rats were investigated. The results proved that gastrodin had neuroprotective effect on TBI through alleviating brain deficits, decreasing brain water content, inhibiting neuronal apoptosis, and suppressing oxidative stress in brain tissues of TBI rats. Mechanically, gastrodin upregulated the expression of Nrf2 downstream proteins, suggesting the activation of Nrf2 pathway in brain tissues of TBI rats. In conclusion, gastrodin provided neuroprotection in TBI rats via Nrf2 pathway.

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来源期刊

Quality Assurance and Safety of Crops & Foods FOOD SCIENCE & TECHNOLOGY-

CiteScore

4.60

自引率

7.50%

发文量

审稿时长

1 months

期刊介绍： ''Quality Assurance and Safety of Crops & Foods'' is an international peer-reviewed journal publishing research and review papers associated with the quality and safety of food and food sources including cereals, grains, oilseeds, fruits, root crops and animal sources. It targets both primary materials and their conversion to human foods. There is a strong focus on the development and application of new analytical tools and their potential for quality assessment, assurance, control and safety. The scope includes issues of risk assessment, traceability, authenticity, food security and socio-economic impacts. Manuscripts presenting novel data and information that are likely to significantly contribute to scientific knowledge in areas of food quality and safety will be considered. ''Quality Assurance and Safety of Crops & Foods'' provides a forum for all those working in the specialist field of food quality and safety to report on the progress and outcomes of their research.