L-肉碱对实验性结肠吻合口伤口的愈合作用

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Marmara Medical Journal Pub Date : 2023-01-16 DOI:10.5472/marumj.1307971

Emel Kandaş, M. Edremitlioğlu, U. Demir, G. Erbil, M. H. Sehitoglu

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引用次数: 0

摘要

目的：观察左旋肉碱对实验性结肠吻合口损伤早期和晚期愈合的影响。材料与方法：选用雌性Wistar Albino大鼠40只。将大鼠分为4组（CONT-3、CONT-7、CARN-3和CARN-7）。在吻合后第3天评估CONT-3组和第7天评估CONT-7组的损伤愈合情况。手术后，CARN-3和CARN-7组腹膜内给予100mg/kg/天的L-肉碱，并在第3天和第7天评估损伤愈合情况。在吻合区的组织样本中测定损伤强度、组织学评价、抗氧化酶活性和氧化损伤。结果：CARN-3组的爆裂压力水平和组织学评分均高于CONT-3组（p

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Healing effects of L-carnitine on experimental colon anastomosis wound

Objective: The purpose of this study is to examine the effects of L-carnitine on healing of experimental colon anastomosis injury in early and late period. Materials and Methods: Forty female Wistar-Albino rats were used in this study. The rats were divided into 4 groups (CONT-3, CONT- 7, CARN-3, and CARN-7). Injury healing was evaluated for CONT-3 group on the 3rd day and for CONT-7 group on the 7th day following the anastomosis. Following the operation, CARN-3 and CARN-7 groups were intraperitoneally administered with 100 mg/ kg/day L-carnitine and injury healing was evaluated on the 3rd and 7th days. Injury strength, histological evaluation and antioxidant enzyme activities and oxidant damage were determined in tissue samples of anastomosis area. Results: Bursting pressure levels and histological scoring values of CARN-3 group were found to be higher than the CONT-3 group (p

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来源期刊

Marmara Medical Journal MEDICINE, GENERAL & INTERNAL-

CiteScore

0.30

自引率

0.00%

发文量

期刊介绍： Marmara Medical Journal, Marmara Üniversitesi Tıp Fakültesi tarafından yılda üç kere yayımlanan multidisipliner bir dergidir. Bu dergide tıbbın tüm alanlarına ait orijinal araştırma makaleleri, olgu sunumları ve derlemeler İngilizce veya Türkçe olarak yer alır.