华北农村高危人乳头瘤病毒基因型流行分布及宫颈癌前病变归因

IF 7 2区 医学 Q1 ONCOLOGY
Shuang Zhao, Xuelian Zhao, Shangying Hu, Jessica Lu, X. Duan, Xun Zhang, Feng Chen, F. Zhao
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The samples of women who tested positive for HPV were retested with a polymerase chain reaction (PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus (HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method. Results A total of 22.2% (2,112/9,526) of women were HR-HPV positive and HPV52 (21.7%) was the most common HR-HPV genotype, followed by HPV58 (18.2%), HPV53 (18.2%) and HPV16 (16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia (CIN)1 were HPV16 (36.7%), HPV58 (20.4%), HPV56 (15.3%). Among CIN2+, the most frequent genotypes were HPV16 (75.6%), HPV52 (17.8%), HPV58 (16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions, and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions. 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引用次数: 14

摘要

目的由于中国人口众多,人乳头瘤病毒(HPV)感染率高,以及中低收入国家(LMICs)对筛查和治疗策略的愿景,对宫颈癌的精确预防更为迫切。考虑结合类型特异性患病率和高级别宫颈上皮内瘤变的归因比例,可以为更精确和有效的区域特异性宫颈癌预防和控制计划提供信息。本研究的目的是确定中国北方农村地区妇女中HPV的基因型分布和宫颈癌前病变的归因。方法对9526名农村妇女进行宫颈癌筛查。对HPV检测呈阳性的妇女样本进行了基于聚合酶链反应(PCR)的HPV基因分型检测。采用类型贡献权重法计算不同级别宫颈病变特定高危型人乳头瘤病毒(HR-HPV)的归因比例。结果共有22.2%(2,112/9,526)的女性HR-HPV阳性,以HPV52基因型(21.7%)最为常见,其次是HPV58基因型(18.2%)、HPV53基因型(18.2%)和HPV16基因型(16.2%)。hr - hpv阳性宫颈上皮内瘤变(CIN)1中检出的前3位基因型分别为HPV16(36.7%)、HPV58(20.4%)、HPV56(15.3%)。在CIN2+中,最常见的基因型是HPV16(75.6%)、HPV52(17.8%)和HPV58(16.7%)。HPV16、56、58、53、52、59、68、18联合占所有CIN1病变的84.17%,HPV16、58、52联合占所有CIN2+病变的86.98%。结论华北农村妇女HR-HPV感染率较高,HPV16、HPV58、HPV52在CIN2+中占最大归因比例。在这一人群中开发疫苗和筛查策略时,应考虑特定类型的HPV患病率和宫颈癌前病变的归因比例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North China
Objective Precise prevention is more desired for cervical cancer due to the huge population, high prevalence of human papillomavirus (HPV) infection in China and the vision of screen-and-treat strategies in low- and middle-income countries (LMICs). Considerations of combining type-specific prevalence and attribution proportion to high-grade cervical intraepithelial neoplasia are informative to more precise and effective region-specific cervical cancer prevention and control programs. The aim of the current study was to determine the genotype distribution of HPV and attribution to cervical precancerous lesions among women from rural areas in North China. Methods A total of 9,526 women participated in the cervical cancer screening project in rural China. The samples of women who tested positive for HPV were retested with a polymerase chain reaction (PCR)-based HPV genotyping test. The attribution proportion of specific high-risk human papillomavirus (HR-HPV) types for different grades of cervical lesions was calculated by using the type contribution weighting method. Results A total of 22.2% (2,112/9,526) of women were HR-HPV positive and HPV52 (21.7%) was the most common HR-HPV genotype, followed by HPV58 (18.2%), HPV53 (18.2%) and HPV16 (16.2%). The top three genotypes detected in HR-HPV-positive cervical intraepithelial neoplasia (CIN)1 were HPV16 (36.7%), HPV58 (20.4%), HPV56 (15.3%). Among CIN2+, the most frequent genotypes were HPV16 (75.6%), HPV52 (17.8%), HPV58 (16.7%). HPV16, 56, 58, 53, 52, 59, 68, and 18 combined were attributed to 84.17% of all CIN1 lesions, and HPV16, 58, and 52 combined were attributed to 86.98% of all CIN2+ lesions. Conclusions The prevalence of HR-HPV infection among women from rural areas in North China was high and HPV16, HPV58, HPV52 had paramount attributable fraction in CIN2+. Type-specific HPV prevalence and attribution proportion to cervical precancerous lesions should be taken into consideration in the development of vaccines and strategy for screening in this population.
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来源期刊
自引率
9.80%
发文量
1726
审稿时长
4.5 months
期刊介绍: Chinese Journal of Cancer Research (CJCR; Print ISSN: 1000-9604; Online ISSN:1993-0631) is published by AME Publishing Company in association with Chinese Anti-Cancer Association.It was launched in March 1995 as a quarterly publication and is now published bi-monthly since February 2013. CJCR is published bi-monthly in English, and is an international journal devoted to the life sciences and medical sciences. It publishes peer-reviewed original articles of basic investigations and clinical observations, reviews and brief communications providing a forum for the recent experimental and clinical advances in cancer research. This journal is indexed in Science Citation Index Expanded (SCIE), PubMed/PubMed Central (PMC), Scopus, SciSearch, Chemistry Abstracts (CA), the Excerpta Medica/EMBASE, Chinainfo, CNKI, CSCI, etc.
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