循环肿瘤DNA的临床监测与早期检测

IF 4.7 2区医学 Q1 ONCOLOGY

Annual Review of Cancer Biology-Series Pub Date : 2019-03-04 DOI:10.1146/ANNUREV-CANCERBIO-030518-055719

R. Corcoran

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引用次数: 7

摘要

在循环血液中存在无细胞DNA（cfDNA）大约70年后，cfDNA已成为临床肿瘤学中的一项变革性技术。通过常规非侵入性抽血评估肿瘤DNA的存在、水平和组成的能力为广泛的高影响力临床应用打开了大门。虽然cfDNA作为一种无需侵入性活组织检查的肿瘤突变谱分析方法正在迅速获得临床青睐，但在临床监测和癌症早期检测领域的新兴应用前景巨大。本文综述了cfDNA的应用进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Circulating Tumor DNA: Clinical Monitoring and Early Detection

Roughly 70 years after the presence of cell-free DNA (cfDNA) in circulating blood was discovered, cfDNA has emerged as a transformative technology in clinical oncology. The ability to assess the presence, level, and composition of tumor DNA from a routine, noninvasive blood draw has opened the door to a broad array of high-impact clinical applications. While cfDNA is rapidly gaining clinical favor as a means of tumor mutational profiling without the need for an invasive biopsy, emerging applications in the areas of clinical monitoring and early cancer detection hold tremendous promise. These developing applications of cfDNA are reviewed herein.

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来源期刊

Annual Review of Cancer Biology-Series Medicine-Oncology

CiteScore

14.50

自引率

1.30%

发文量

期刊介绍： The Annual Review of Cancer Biology offers comprehensive reviews on various topics within cancer research, covering pivotal and emerging areas in the field. As our understanding of cancer's fundamental mechanisms deepens and more findings transition into targeted clinical treatments, the journal is structured around three main themes: Cancer Cell Biology, Tumorigenesis and Cancer Progression, and Translational Cancer Science. The current volume of this journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, ensuring all articles are published under a CC BY license.