靶向细胞衰老对抗癌症和衰老

IF 5 2区医学 Q1 ONCOLOGY

Molecular Oncology Pub Date : 2022-06-08 DOI:10.1002/1878-0261.13266

Chen Wang, Xue Hao, Rugang Zhang

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引用次数: 4

摘要

衰老是一个复杂的细胞过程，涉及各种生理和病理过程。其特征是细胞生长停滞的稳定状态以及多种促炎因子、趋化因子和生长因子的分泌组。在这篇综述中，我们总结了细胞衰老在衰老和年龄相关疾病（如癌症）中的上下文依赖性作用。我们讨论了目前针对衰老的方法，以制定对抗癌症和促进健康衰老的治疗策略，并概述了我们对这些领域基于衰老的干预措施的未来研究方向的愿景。

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Targeting cellular senescence to combat cancer and ageing

Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth factors. In this review, we summarize the context‐dependent role of cellular senescence in ageing and in age‐related diseases, such as cancer. We discuss current approaches to targeting senescence to develop therapeutic strategies to combat cancer and to promote healthy ageing, and we outline our vision for future research directions for senescence‐based interventions in these fields.

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来源期刊

Molecular Oncology 医学-肿瘤学

CiteScore

12.60

自引率

1.50%

发文量

203

审稿时长

6-12 weeks

期刊介绍： Molecular Oncology highlights new discoveries, approaches, and technical developments, in basic, clinical and discovery-driven translational cancer research. It publishes research articles, reviews (by invitation only), and timely science policy articles. The journal is now fully Open Access with all articles published over the past 10 years freely available.