肝细胞癌动脉期CT特征与分化程度及PCNA、PTEN表达的相关性

Pub Date : 2022-11-03 DOI:10.31901/24566330.2022/22.04.833

Wei Wang

{"title":"肝细胞癌动脉期CT特征与分化程度及PCNA、PTEN表达的相关性","authors":"Wei Wang","doi":"10.31901/24566330.2022/22.04.833","DOIUrl":null,"url":null,"abstract":"The purpose of this study was to explore the correlations of the arterial-phase enhanced CT characteristics of hepatocellular carcinoma (HCC) with the differentiation degree and expressions of proliferating cell nuclear antigen (PCNA) and phosphatase and tensin homologue (PTEN). Seventy-nine HCC patients who underwent three-phase dynamic contrast-enhanced CT before surgery were selected to observe the arterial-phase characteristics. The degree of HCC tissue differentiation was evaluated by hematoxylin-eosin staining. PCNA and PTEN expressions were detected by immunohistochemistry. Spearman’s correlation analysis was conducted. The tumour size and vascular enhancement characteristics were negatively correlated with HCC differentiation degree and PTEN expression, and positively correlated with PCNA expression. The capsule integrity was positively correlated with HCC differentiation degree and PTEN expression, and negatively correlated with PCNA expression. The arterial-phase CT characteristics of HCC reflect the differentiation degree and expressions of PCNA and PTEN.","PeriodicalId":0,"journal":{"name":"","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlations of Arterial Phase CT Characteristics of Hepatocellular Carcinoma with Differentiation Degree and Expressions of PCNA and PTEN\",\"authors\":\"Wei Wang\",\"doi\":\"10.31901/24566330.2022/22.04.833\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The purpose of this study was to explore the correlations of the arterial-phase enhanced CT characteristics of hepatocellular carcinoma (HCC) with the differentiation degree and expressions of proliferating cell nuclear antigen (PCNA) and phosphatase and tensin homologue (PTEN). Seventy-nine HCC patients who underwent three-phase dynamic contrast-enhanced CT before surgery were selected to observe the arterial-phase characteristics. The degree of HCC tissue differentiation was evaluated by hematoxylin-eosin staining. PCNA and PTEN expressions were detected by immunohistochemistry. Spearman’s correlation analysis was conducted. The tumour size and vascular enhancement characteristics were negatively correlated with HCC differentiation degree and PTEN expression, and positively correlated with PCNA expression. The capsule integrity was positively correlated with HCC differentiation degree and PTEN expression, and negatively correlated with PCNA expression. The arterial-phase CT characteristics of HCC reflect the differentiation degree and expressions of PCNA and PTEN.\",\"PeriodicalId\":0,\"journal\":{\"name\":\"\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0,\"publicationDate\":\"2022-11-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.31901/24566330.2022/22.04.833\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.31901/24566330.2022/22.04.833","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

本研究旨在探讨肝细胞癌(HCC)动脉期增强CT特征与增殖细胞核抗原(PCNA)、磷酸酶及紧张素同源物(PTEN)分化程度及表达的相关性。选择术前行三期动态增强CT的HCC患者79例，观察其动脉期特征。苏木精-伊红染色评价HCC组织分化程度。免疫组织化学检测PCNA和PTEN的表达。进行Spearman相关分析。肿瘤大小、血管增强特征与HCC分化程度、PTEN表达呈负相关，与PCNA表达呈正相关。囊完整性与HCC分化程度、PTEN表达呈正相关，与PCNA表达负相关。HCC的动脉期CT特征反映了PCNA和PTEN的分化程度及表达。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文

Correlations of Arterial Phase CT Characteristics of Hepatocellular Carcinoma with Differentiation Degree and Expressions of PCNA and PTEN

The purpose of this study was to explore the correlations of the arterial-phase enhanced CT characteristics of hepatocellular carcinoma (HCC) with the differentiation degree and expressions of proliferating cell nuclear antigen (PCNA) and phosphatase and tensin homologue (PTEN). Seventy-nine HCC patients who underwent three-phase dynamic contrast-enhanced CT before surgery were selected to observe the arterial-phase characteristics. The degree of HCC tissue differentiation was evaluated by hematoxylin-eosin staining. PCNA and PTEN expressions were detected by immunohistochemistry. Spearman’s correlation analysis was conducted. The tumour size and vascular enhancement characteristics were negatively correlated with HCC differentiation degree and PTEN expression, and positively correlated with PCNA expression. The capsule integrity was positively correlated with HCC differentiation degree and PTEN expression, and negatively correlated with PCNA expression. The arterial-phase CT characteristics of HCC reflect the differentiation degree and expressions of PCNA and PTEN.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助