T细胞恶性肿瘤中的自发性肿瘤溶解综合征:两例报告。

Q1 Biochemistry, Genetics and Molecular Biology
W. Roque, A. Rehman, G. Suero-Abreu, B. Danek, Joseph Colao, Alla Fayngersh, S. Srinivas, J. Kra, D. Cai, V. Chang
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引用次数: 5

摘要

肿瘤溶解综合征(TLS)是指由快速死亡的肿瘤细胞释放细胞内溶质(钾、磷酸盐和核酸代谢产物)引起的一系列代谢异常。虽然TLS最常见于化疗后,但自发性TLS很少发生在快速分裂的液体或固体恶性肿瘤中。在这里,我们报告了两名患者的病例,他们表现出非特异性症状,并被发现患有自发性TLS。对这两个病例的研究都导致了T细胞恶性肿瘤(即急性淋巴细胞白血病和血管免疫母细胞淋巴瘤)的诊断。鉴于自发性TLS可能是潜在恶性肿瘤的第一表现,所有医生都应该熟悉这种肿瘤学紧急情况。早期识别和及时处理可以挽救原本可以治愈的恶性肿瘤患者的生命。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Spontaneous tumor lysis syndrome in T-cell malignancy: two case reports.
Tumor lysis syndrome (TLS) refers to a constellation of metabolic abnormalities that result from release of intracellular solutes (potassium, phosphate, and nucleic acid metabolites) from rapidly dying tumor cells. While TLS most commonly occurs following chemotherapy, spontaneous TLS can rarely occur in rapidly dividing liquid or solid malignancies. Here, we report the cases of two patients who presented with non-specific symptoms and were found to have spontaneous TLS. Work-up in both cases led to a diagnosis of T-cell malignancy (i.e., acute lymphoblastic leukemia and angioimmunoblastic lymphoma). Given that spontaneous TLS can be the first manifestation of an underlying malignancy, all physicians should be familiar with this oncologic emergency. Early recognition and prompt management can be lifesaving for patients with an otherwise curable malignancy.
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来源期刊
Stem cell investigation
Stem cell investigation Biochemistry, Genetics and Molecular Biology-Developmental Biology
CiteScore
5.80
自引率
0.00%
发文量
9
期刊介绍: The Stem Cell Investigation (SCI; Stem Cell Investig; Online ISSN: 2313-0792) is a free access, peer-reviewed online journal covering basic, translational, and clinical research on all aspects of stem cells. It publishes original research articles and reviews on embryonic stem cells, induced pluripotent stem cells, adult tissue-specific stem/progenitor cells, cancer stem like cells, stem cell niche, stem cell technology, stem cell based drug discovery, and regenerative medicine. Stem Cell Investigation is indexed in PubMed/PMC since April, 2016.
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