The elimination period of ivermectin residuals from the body of broiler chickens after Iverbutan

The purpose of the research is to study the elimination period of Ivermectin residuals after three oral administrations of Iverbutan to broiler chickens.Materials and methods. For the experiment, 18 broiler chickens aged 28 days were selected. The birds were kept in the conditions of the Podolsk Experimental Production Department of the VNIIP – FSC VIEV. Iverbutan contains 0.4% of ivermectin and 10.0% of butaphosphan as active substances. The drug was administered orally by the group method at the rate of 1.0 mL of Iverbutan per 1 Liter of drinking water. Iverbutan was given three times: twice with a 24-hour interval and once after 14 days. The birds were killed and samples of their organs and tissues were taken at 9, 14, and 19 days after the drug was administered three times. Organs and tissues of each following type were collected from 6 birds: muscles, liver, kidneys, and skin with subcutaneous adipose tissue. The technique was based on the determination of Ivermectin by high performance liquid chromatography with modified pre-column accomplished with N-methylimidazole and trifluoroacetic anhydride, followed by fluorescence detection. The quantification was performed by the internal standardization.Results and discussion. The period was studied for elimination of Ivermectin residuals from the chickens’ body after the drug was administered three times. The residuals that exceed the maximum allowable levels were determined at 9 and 14 days after the drug was completed. It was found that the chickens’ organs and tissues did not contain Ivermectin at 19 days. Thus, poultry meat can be used for food at 19 days after Iverbutan is administered three times.