基于智能计算的光谱学与化学计量辅助方法的临界评估:在联合抗生素制剂中的应用

H. A. Abdullatif, A. Michael, Y. A. Trabik, Miriam F. Ayad
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引用次数: 0

摘要

本工作描述了两种多变量化学计量法和单变量分光光度法的比较研究,用于测定含有盐酸土霉素、盐酸溴己新和盐酸利多卡因的三元药物混合物。所有方法都显示出高灵敏度和相似的线性范围。同时,化学计量法具有准确性高、特异性强、回归参数好的优点。两种分光光度法是常数乘法与光谱减法和逐次比值减法与光谱减法相结合,而化学计量法使用偏最小二乘和主成分回归模型。此外,使用加标技术来增加剂型中盐酸溴己新的浓度,尽管其贡献很低,但仍能进行测定。方法已成功应用于纯粉末形式的Oxyclear®兽医注射液及其药物配方中。统计比较表明,所开发的方法与参考方法之间没有显著差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Critical assessment of smart calculation-based spectroscopy versus chemometric-assisted methods: Application to combined antibiotic formulations
This work describes a comparative study of two multivariate chemometric and univariate spectrophotometric methods for the determination of a ternary drug mixture containing oxytetracycline HCl, bromhexine HCl, and lidocaine HCl. All methods show high sensitivity and similar linearity range. Meanwhile, the chemometric method has the advantage of higher accuracy, higher specificity and better regression parameters. The two spectrophotometric methods are constant multiplication coupled with spectrum subtraction and successive ratio subtraction coupled with spectrum subtraction while the chemometric method used partial least square and principal component regression models. In addition, a spiking technique was used to increase the concentration of bromhexine HCl in the dosage form, allowing its determination despite its low contribution. Methods were successfully applied in the dosage form Oxyclear® veterinary injection in pure powder as well as in its pharmaceutical formulation. Statistical comparison showed no significant difference between the developed methods and the reference method.
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