自身免疫性脑炎与睡眠障碍

Q4 Medicine

中国现代神经疾病杂志 Pub Date : 2017-10-25 DOI:10.3969/cjcnn.v17i10.1672

Y. Huang, Hong-lin Hao

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引用次数: 0

摘要

研究表明，自身免疫性脑炎与睡眠障碍有关。具有Ma2抗体的副肿瘤性神经综合征（PNS）可导致睡眠障碍，特别是发作性睡病和快速眼动睡眠行为障碍（RBD）。边缘脑炎（LE）和Morvan综合征与电压门控钾通道（VGKC）复合物抗体相关，包括富含亮氨酸的胶质瘤失活1（LGI1）抗体和接触蛋白相关蛋白2（Caspr2），可导致严重失眠和其他睡眠障碍。在抗N-甲基-D-天冬氨酸（NMDA）受体脑炎患者中发现了中枢神经源性低通气，而阻塞性睡眠呼吸暂停（OSA）、喘鸣和睡眠障碍是与IgLON5抗体相关的脑病的突出特征。睡眠障碍是自身免疫性脑炎患者的主要表现。免疫治疗可能以积极的方式改善临床症状和预后。DOI:10.3969/j.issn.1672-6731017.10.004

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Autoimmune encephalitis and sleep disorders

Research shows that autoimmune encephalitis is associated with sleep disorders. Paraneoplastic neurological syndrome (PNS) with Ma2 antibodies can cause sleep disorders, particularly narcolepsy and rapid eye movement sleep behavior disorder (RBD). Limbic encephalitis (LE) and Morvan syndrome, associated with voltage - gated potassium channel (VGKC)-complex antibodies, which include leucine-rich glioma-inactivated 1 (LGI1) antibody and contactin-associated protein 2 (Caspr2), can result in profound insomnia and other sleep disorders. Central neurogenic hypoventilation are found in patients with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis, whereas obstructive sleep apnea (OSA), stridor and parasomnia are prominent features of encephalopathy associated with IgLON5 antibodies. Sleep disorders are cardinal manifestations in patients with autoimmune encephalitis. Immunotherapy possiblely can improve clinical symptoms and prognosis in a positive way. DOI: 10.3969/j.issn.1672-6731.2017.10.004

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