苦参花提取物的植物化学成分分析及其α-淀粉酶和α-葡萄糖苷酶抑制作用

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2023-04-18 DOI:10.2174/1573408019666230418114015

Boussoussa Hadjer, Benabed Khadidja Houda, Khacheba Ihcen, Yousfi Mohamed

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引用次数: 0

摘要

非洲蕨是在阿尔及利亚撒哈拉沙漠发现的一种特有的沙漠植物，它被当地居民用于奶酪生产和民间医药作为抗利尿剂和抗菌剂。本研究采用气相色谱-质谱联用技术分析了牛蒡草提取物的植物化学成分，并评价了其对糖尿病相关的α-淀粉酶和α-葡萄糖苷酶的抑制作用。采用石油醚和二氯甲烷两种溶剂进行萃取。然后用GC-MS分析所得提取物，并在体外测试其抗糖尿病活性。气相色谱-质谱分析结果显示，苦参花提取物中含有(-)- spathulenol、α等多种化合物。-石油醚提取物中的amyrin、Lupeol和cedar -diol;二氯甲烷萃取物中的h -环丙[e]azulen-7-ol, 5(1H)-Azulenone和-cardinol。与二氯甲烷提取物相比，石油醚提取物具有较好的体外抗糖尿病活性。本研究证实了石油醚提取物与二氯甲烷提取物的抗糖尿病活性;还需要进行其他的研究来纯化和在体内研究苦参的生物化合物。本研究为牛蒡花具有体外抗糖尿病作用提供了科学依据。

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Phytochemical constituents’ analysis of Rhanterium adpressum Coss & Durieu flowers extracts and their α-amylase and α-glucosidase inhibition properties

Rhanterium adpressum is an endemic and desert plant found in Algerian Sahara, it is used by the local population in cheese production and folk medicine as an antidiuretic and antimicrobial. This study aimed to analyse the phytochemical composition of Rhanterium adpressum extracts by GC-MS and assess their inhibitory potential on α-amylase and α-glucosidase enzymes linked to diabetes. Two solvents were used for extraction: petroleum ether and dichloromethane. The obtained extracts were then analysed by GC-MS and in vitro tested for their antidiabetic activity. GC-MS analysis of extracts from R. adpressum flowers revealed various phytocompounds, such as (-)-Spathulenol, alpha.-Amyrin, Lupeol and Cedran-diol in petroleum ether extract; 1H-Cycloprop[e]azulen-7-ol, 5(1H)-Azulenone and alpha-cardinol in dichloromethane extract. Petroleum ether extract exhibited a good in vitro antidiabetic activity in comparison to dichloromethane extract. This research confirms the antidiabetic activity of petroleum ether extract when compared with dichloromethane extract; other studies are needed for purification and in vivo study of bio-compounds from Rhanterium adpressum. This investigation offers scientific data that flowers of Rhanterium adpressum exhibit in vitro anti-diabetic effect.

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.