表观遗传学与法医学：照亮未来

Q2 Pharmacology, Toxicology and Pharmaceutics

Current Bioactive Compounds Pub Date : 2023-08-15 DOI:10.2174/1573407219666230815105041

P. Astaraki, Bareza Rezaei, M. Ahadi

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引用次数: 0

摘要

表观遗传学处理的是与某些表观遗传元件有关的基因表达的变化（遗传密码没有变化）对环境的反应。一些最常见的表观遗传学例子包括DNA甲基化、组蛋白修饰和非编码RNA。该领域已被广泛应用于法医学研究，特别是确定体液类型，将其与混合样本区分开来，揭示法医样本的生物年龄和基于药物的研究。考虑到最近的发现，这篇综述强调了表观遗传学在法医学调查中的应用。

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Epigenetics and Forensics: Brightening the Future

Epigenetics deals with the changes in gene expression (no change in the genetic code) concerning certain epigenetic elements in response to the environment. Some of the most common epigenetic examples include DNA methylation, histone modifications, and non-coding RNAs. This field has been extensively applied in forensic studies, particularly to determine types of body fluids, distinguish them from mixed samples, uncovering the biological age of the forensic samples and drug-based studies. Considering recent findings, this review highlights the applications of epigenetics in forensic investigations.

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来源期刊

Current Bioactive Compounds Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

1.90

自引率

0.00%

发文量

112

期刊介绍： The journal aims to provide comprehensive review articles on new bioactive compounds with proven activities in various biological screenings and pharmacological models with a special emphasis on stereoeselective synthesis. The aim is to provide a valuable information source of bioactive compounds synthesized or isolated, which can be used for further development of pharmaceuticals by industry and academia. The journal should prove to be essential reading for pharmacologists, natural product chemists and medicinal chemists who wish to be kept informed and up-to-date with the most important developments on new bioactive compounds of natural or synthetic origin, including their stereoeselective synthesis.