JAK-STAT通路在胶质瘤血管生成中的研究进展

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.11.019

Xin-rui Yang

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引用次数: 0

摘要

血管营养传递是肿瘤形成过程中不可替代的因素。阻断或减少肿瘤的能量传递途径可以有效地抵抗肿瘤的发展。JAK-STAT信号通路与血管生成有着密切的关系，特别是近年来对该通路与血管内皮生长因子（VEGF）信号关系的研究取得了许多成果。本文综述了血管生成的诱导、药物开发以及JAK通路中抗血管生成靶点的发现，为神经胶质瘤的治疗提供了一些思路。关键词：胶质瘤；血管内皮生长因子；JAK-STAT；血管生成

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Progress of JAK-STAT pathway in the angiogenesis of glioma

Vascular nutrition transmission is an irreplaceable factor in the process of tumor formation. Blocking or reducing the energy transmission pathway of tumor can effectively resist the development of tumor. There is a close relationship between JAK-STAT signaling pathway and angiogenesis, especially research on the relationship between this pathway and vascular endothelial growth factor (VEGF) signal has produced many results in recent years. This review summarizes the induction of angiogenesis, drug development, and the discovery of antiangiogenic targets in the JAK pathway, providing some ideas for the treatment of glioma. Key words: Glioma; Vascular endothelial growth factors; JAK-STAT; Angiogenesis

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.