上尿路癌根治性肾输尿管切除术后并发原位癌的预后价值:一项系统回顾和meta分析

Q4 Medicine

中华泌尿外科杂志 Pub Date : 2020-01-15 DOI:10.3760/CMA.J.ISSN.1000-6702.2020.01.010

Lijin Zhang, Z. Zha, Hu Zhao, Jun Yuan, P. Guo, Yejun Feng

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引用次数: 0

摘要

目的通过系统评价和荟萃分析，探讨合并原位癌(CCIS)对上尿路癌(UTUC)患者肿瘤生存的影响。方法根据PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analysis)指南，系统检索Web of Science、PubMed、EMBASE中国国家知识基础设施(CNKI)和万方数据库，检索关键词为“上尿路尿路上皮癌”、“肾口癌”、“合并原位癌”、“根治性输尿管切除术”的所有报道，并对CCIS的预测因素进行详细结果分析。搜索截止日期为2019年6月，搜索词为英文和中文。采用QUIPS工具进行方法学质量评价，使用Stata 12.0和RevMan 5.3软件对相关数据进行统计分析。结果本研究纳入16篇文章，均发表于2012 - 2019年。共11131例UTUC患者，其中CCIS患者1774例(15.9%)。根据我们的最终结果，CCIS与较差的癌症特异性生存(CSS) (HR=1.10, 95%CI 1.05-1.16, P<0.001)、无复发生存(RFS) (HR=1.15, 95%CI 1.09-1.21, P<0.001)和总生存(OS) (HR=1.10, 95%CI 1.03-1.17, P=0.003)有显著相关性。Begg偏倚分析显示，CSS (P=0.822)、RFS (P=0.348)和OS (P=0.452)均无显著发表偏倚。结论CCIS与不良的肿瘤预后相关，可作为根治性肾输尿管切除术后UTUC患者的独立预后因素。关键词:泌尿系统疾病;上尿路癌;激进nephroureterectomy;伴发原位癌;预后;荟萃分析

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The prognostic value of concomitant carcinoma in situ in patients with upper tract urinary carcinoma after radical nephroureterectomy: an systematic review and Meta-analysis

Objective The aim of this study was to evaluate the influence of concomitant carcinoma in situ (CCIS) on tumor survival for the upper tract urinary carcinoma (UTUC) through systematic review and meta-analysis. Methods In the light of Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, a systematic search of Web of Science, PubMed and EMBASE China National Knowledge Infrastructure (CNKI) and Wanfang database by key words "upper urinary tract urothelial carcinoma" "renal sputum cancer" "concomitant carcinoma in situ" , and "radical ureterectomy" were performed for all reports that included detailed results on the predictors of CCIS. The search deadline is June 2019, and the search terms are English and Chinese. Methodological quality evaluation was performed using the QUIPS tool, and statistical analysis of the relevant data was performed using Stata 12.0 and RevMan 5.3 software. Results Sixteen articles were included in this study and all published between 2012 and 2019. A total of 11 131 patients with UTUC, including 1 774 (15.9%) patients with CCIS. According to our final results, there was a significant correlation of CCIS with worse cancer-specific survival (CSS) (HR=1.10, 95%CI 1.05-1.16, P<0.001), recurrence-free survival (RFS) (HR=1.15, 95%CI 1.09-1.21, P<0.001) and overall survival (OS) (HR=1.10, 95%CI 1.03-1.17, P=0.003). Begg′s bias analysis showed no significant publication bias in CSS (P=0.822), RFS (P=0.348), and OS (P=0.452). Conclusions This study demonstrated that CCIS was associated with poor oncological outcome and could serve as a independent prognostic factor for patient with UTUC after radical nephroureterectomy. Key words: Urologic diseases; Upper tract urinary carcinoma; Radical nephroureterectomy; Concomitant carcinoma in situ; Prognosis; Meta-analysis

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来源期刊

中华泌尿外科杂志 Medicine-Nephrology

CiteScore

0.10

自引率

0.00%

发文量

14180

期刊介绍： Chinese Journal of Urology (monthly) was founded in 1980. It is a publicly issued academic journal supervised by the China Association for Science and Technology and sponsored by the Chinese Medical Association. It mainly publishes original research papers, reviews and comments in this field. This journal mainly reports on the latest scientific research results and clinical diagnosis and treatment experience in the professional field of urology at home and abroad, as well as basic theoretical research results closely related to clinical practice. The journal has columns such as treatises, abstracts of treatises, experimental studies, case reports, experience exchanges, reviews, reviews, lectures, etc. Chinese Journal of Urology has been included in well-known databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Chinese Science Citation Database Source Journal (including extended version), and also included in American Chemical Abstracts (CA). The journal has been rated as a quality journal by the Association for Science and Technology and as an excellent journal by the Chinese Medical Association.