Patricia Abigail Arias Yrazusta, Gladys Maribel Godoy Torales, G. Samudio, C. Aparicio
{"title":"两性霉素B脱氧胆酸盐对意大利国立医院新生儿的不良反应","authors":"Patricia Abigail Arias Yrazusta, Gladys Maribel Godoy Torales, G. Samudio, C. Aparicio","doi":"10.18004/RDN2018.0010.01.017-035","DOIUrl":null,"url":null,"abstract":"Introduction: in recent decades, the agent of choice for the treatment of Artículo original Efectos adversos de anfotericina B desoxicolato en neonatos del Hospital Nacional de Itauguá Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá Patricia Abigail Arias Yrazusta, Gladys Godoy Torales, Gloria Samudio, Chantal Marie Real Aparicio DEL NACIONAL Rev. Nac (Itauguá) 2018;10(1):017-035 10.18004/rdn2018.0010.01.017-035 most systemic mycoses has been amphotericin B which, despite the toxic effects, continues to play an important role in the treatment of fungal infections. Objective: to determine the adverse effects associated with the use of amphotericin B in neonates of the Neonatology Service of the National Hospital of Itauguá, in the period 2013 2015. Materials and methods: retrospective case series study of newborns treated with amphotericin B. Results: among 28 newborns treated with amphotericin B, there was a higher prevalence in males. With regard to age, more than half of the newborns were pre-term in the group studied. There was a predominance of low birth weight (32.14%). The risk factors showed that 53.5% did not have a history of sepsis. The mean age of onset of amphotericin was 19 ± 9 days, more than half of the infants used progressive dose from 0.5 mg / kp / day to 1 mg / kp / day, in 24 hours. 96.4% received infusion of amphotericin B for 4 hours, 1 case required 6 hours. Among the side effects, 35.7% of the patients presented anemia, the most frequent water and electrolyte disturbance was hypokalemia, among the signs were tachycardia and hypotension. Conclusions: the most striking side effects found during treatment with amphotericin B were anemia, Sodium and Potassium alterations.","PeriodicalId":52884,"journal":{"name":"Revista del Nacional Itaugua","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2018-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá\",\"authors\":\"Patricia Abigail Arias Yrazusta, Gladys Maribel Godoy Torales, G. Samudio, C. Aparicio\",\"doi\":\"10.18004/RDN2018.0010.01.017-035\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction: in recent decades, the agent of choice for the treatment of Artículo original Efectos adversos de anfotericina B desoxicolato en neonatos del Hospital Nacional de Itauguá Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá Patricia Abigail Arias Yrazusta, Gladys Godoy Torales, Gloria Samudio, Chantal Marie Real Aparicio DEL NACIONAL Rev. Nac (Itauguá) 2018;10(1):017-035 10.18004/rdn2018.0010.01.017-035 most systemic mycoses has been amphotericin B which, despite the toxic effects, continues to play an important role in the treatment of fungal infections. Objective: to determine the adverse effects associated with the use of amphotericin B in neonates of the Neonatology Service of the National Hospital of Itauguá, in the period 2013 2015. Materials and methods: retrospective case series study of newborns treated with amphotericin B. Results: among 28 newborns treated with amphotericin B, there was a higher prevalence in males. With regard to age, more than half of the newborns were pre-term in the group studied. There was a predominance of low birth weight (32.14%). The risk factors showed that 53.5% did not have a history of sepsis. The mean age of onset of amphotericin was 19 ± 9 days, more than half of the infants used progressive dose from 0.5 mg / kp / day to 1 mg / kp / day, in 24 hours. 96.4% received infusion of amphotericin B for 4 hours, 1 case required 6 hours. Among the side effects, 35.7% of the patients presented anemia, the most frequent water and electrolyte disturbance was hypokalemia, among the signs were tachycardia and hypotension. Conclusions: the most striking side effects found during treatment with amphotericin B were anemia, Sodium and Potassium alterations.\",\"PeriodicalId\":52884,\"journal\":{\"name\":\"Revista del Nacional Itaugua\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2018-06-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Revista del Nacional Itaugua\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.18004/RDN2018.0010.01.017-035\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista del Nacional Itaugua","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.18004/RDN2018.0010.01.017-035","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
简介:近几十年来,Artículo治疗意大利国家医院新生婴儿的首选药物阿替卡林B脱氧胆酸盐对意大利国家医院新生儿的不良影响Patricia Abigail Arias Yrazusta、Gladys Godoy Torales、Gloria Samudio、Chantal Marie Real Aparicio del Nacional Rev。Nac(意大利)2018;10(1):017-035 10.18004/rdn2018.0010.01.017-035大多数系统性真菌病都是两性霉素B,尽管有毒性作用,但它在真菌感染的治疗中仍然发挥着重要作用。目的:确定2013年至2015年期间,意大利国立医院新生儿服务中心在新生儿中使用两性霉素B的不良反应。材料和方法:对接受两性霉素B治疗的新生儿进行回顾性病例系列研究。结果:在接受两性蛋白酶B治疗的28名新生儿中,男性的患病率较高。就年龄而言,研究组中超过一半的新生儿是足月前出生的。以低出生体重为主(32.14%),危险因素显示53.5%无败血症史。两性霉素的平均发病年龄为19±9天,超过一半的婴儿在24小时内使用了从0.5mg/kp/天到1mg/kp/天的渐进剂量。96.4%的患者输注两性霉素B 4小时,1例需输注6小时。在副作用中,35.7%的患者表现为贫血,最常见的水和电解质紊乱是低钾血症,其中体征是心动过速和低血压。结论:两性霉素B治疗期间发现的最显著的副作用是贫血、钠和钾的改变。
Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá
Introduction: in recent decades, the agent of choice for the treatment of Artículo original Efectos adversos de anfotericina B desoxicolato en neonatos del Hospital Nacional de Itauguá Adverse effects of amphotericin B deoxycholate in neonates of the National Hospital of Itauguá Patricia Abigail Arias Yrazusta, Gladys Godoy Torales, Gloria Samudio, Chantal Marie Real Aparicio DEL NACIONAL Rev. Nac (Itauguá) 2018;10(1):017-035 10.18004/rdn2018.0010.01.017-035 most systemic mycoses has been amphotericin B which, despite the toxic effects, continues to play an important role in the treatment of fungal infections. Objective: to determine the adverse effects associated with the use of amphotericin B in neonates of the Neonatology Service of the National Hospital of Itauguá, in the period 2013 2015. Materials and methods: retrospective case series study of newborns treated with amphotericin B. Results: among 28 newborns treated with amphotericin B, there was a higher prevalence in males. With regard to age, more than half of the newborns were pre-term in the group studied. There was a predominance of low birth weight (32.14%). The risk factors showed that 53.5% did not have a history of sepsis. The mean age of onset of amphotericin was 19 ± 9 days, more than half of the infants used progressive dose from 0.5 mg / kp / day to 1 mg / kp / day, in 24 hours. 96.4% received infusion of amphotericin B for 4 hours, 1 case required 6 hours. Among the side effects, 35.7% of the patients presented anemia, the most frequent water and electrolyte disturbance was hypokalemia, among the signs were tachycardia and hypotension. Conclusions: the most striking side effects found during treatment with amphotericin B were anemia, Sodium and Potassium alterations.