棕色脂肪组织与骨骼相互作用的研究进展

Q4 Medicine

中华内分泌代谢杂志 Pub Date : 2019-11-25 DOI:10.3760/CMA.J.ISSN.1000-6699.2019.11.014

Mengyue Sun, Qi Yuan, Jinglei Yang, Ri-Dong Zhang, Shan Tang, Sha Tao

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引用次数: 0

摘要

棕色脂肪组织(BAT)通过解偶联蛋白(UCP1)的作用，以热量的形式直接耗散储存的能量，从而增加能量消耗。最近的研究发现，棕色脂肪细胞也可能通过自分泌、旁分泌和内分泌机制调节代谢。越来越多的证据表明BAT与骨代谢密切相关，其中BAT分泌多种因子调节骨代谢，而骨也分泌多种生物活性物质控制BAT功能。此外，BAT可能通过肌肉介导的调节或SNS活性，改善机体代谢，间接参与骨代谢，从而形成BAT-骨骼轴。在本文中，我们试图解释棕色脂肪组织和骨骼之间的关系，并讨论它们的相互作用机制。关键词:棕色脂肪组织;骨代谢;内分泌因素

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Research progress on the mutual effects between brown adipose tissue and bone

Brown adipose tissue (BAT) increases energy consumption by directly dissipating stored energy in the form of heat through the role of uncoupling protein (UCP1). Recent studies have found that brown adipocytes may also regulate metabolism through autocrine, paracrine, and endocrine mechanisms. A growing body of evidences have shown that the BAT has a close relationship with bone metabolism, in which BAT secretes a variety of factors to regulate bone metabolism, while bone also secretes a variety of bioactive substances to control BAT function. In addition, BAT may indirectly participate in bone metabolism through muscle-mediated regulation or SNS activity and improvement of body metabolism, thus forming a BAT-skeletal axis. In this paper, we try to explain the relationship between brown adipose tissue and bone, and to discuss their interactive mechanisms. Key words: Brown adipose tissue; Bone metabolism; Endocrine factors

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来源期刊

中华内分泌代谢杂志 Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

0.60

自引率

0.00%

发文量

7243

期刊介绍： The Chinese Journal of Endocrinology and Metabolism was founded in July 1985. It is a senior academic journal in the field of endocrinology and metabolism sponsored by the Chinese Medical Association. The journal aims to be the "Chinese broadcaster of new knowledge on endocrinology and metabolism worldwide". It reports leading scientific research results and clinical diagnosis and treatment experience in endocrinology and metabolism and related fields, as well as basic theoretical research that has a guiding role in endocrinology and metabolism clinics and is closely integrated with clinics. The journal is a core journal of Chinese science and technology (a statistical source journal of Chinese science and technology papers), and is included in Chinese and foreign statistical source journal databases such as the Chinese Science and Technology Papers and Citation Database, Chemical Abstracts, and Scopus.