帕金森病:疑似细菌性骨髓炎抗生素治疗后运动症状缓解一例报告

Leheste, Gottlieb Sf, Biegel Ca, Ramos Rl, G. Torres, G. Saggio
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引用次数: 1

摘要

背景和病例:绝大多数帕金森病(PD)病例是偶发性的,没有任何明显的病因模式。这对发现有效的预防和治疗策略构成了重大障碍。我们报告了一例86岁的白人男性,有21年的帕金森病史,在用抗生素治疗疑似细菌性骨髓炎后,帕金森病相关的运动症状完全缓解。结果:右腿受伤后,患者因疑似骨髓炎接受了为期10天的环丙沙星疗程和为期四周的双氯西林疗程。在完成抗生素治疗后,患者报告其普遍的运动症状“完全缓解”,至今仍未复发。结论:帕金森病是一种进行性的、主要是特发性的神经退行性疾病,治疗选择有效但有限,没有令人信服的预防策略。在这里,我们发现了第一个病例,表明在使用抗生素进行不相关的疗程后,PD相关的运动症状得到了解决。这引发了关于PD中抗生素的使用以及病原菌之间潜在联系的有趣问题。帕金森病的微生物组特征是目前研究的“热点”,研究需要继续研究细菌是帕金森病的可能原因,抗生素是有效的治疗方式。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Parkinson’s Disease: A Case Report of Motor Symptoms Resolution Following Antibiotic Treatment for Suspected Bacterial Osteomyelitis
Background and case: The vast majority of Parkinson’s disease (PD) cases occur sporadically without any obvious etiological schema. That poses major hurdles to the discovery of effective preventative and treatment strategies. Here we are reporting the case of an 86-year-old Caucasian male, with a 21-year history of PD, who reports complete resolution of PD - related motor symptoms after treatment with antibiotics for suspected bacterial osteomyelitis.Results: After a right leg injury, the patient was prescribed a ten-day course of ciprofloxacin and a four-week course of dicloxacillin for suspected osteomyelitis. After completion of the antibiotics, the patient reported his pervasive motor symptoms as “completely resolved” which to this day have not returned.Conclusion: PD is a progressive, mostly idiopathic, neurodegenerative disorder with effective but limited treatment options and without compelling preventative strategies. Here we identify the first case indicating the resolution of PD-linked motor symptoms following an unrelated treatment course with antibiotics. This raises interesting questions about the use of antibiotics in PD and the potential of an etiological bacterial connection. The microbiome signature of PD is a current ‘hot topic’ of investigation and studies need to continue investigating bacteria as a possible causes of PD and antibiotics as effective treatment modalities.
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