A Coronavirus Disease-2019 patient presenting with cavernous sinus thrombosis in the second wave of the Coronavirus Disease-2019 pandemic

Rationale: Presenting this case report is of essential importance to shed the light on this rare clinical situation. Patient Concerns: A 68-year-old man presented with generalised weakness, shortness of breath, mild fever and loss of smell and taste for three days. Diagnosis: A filling deficiency of the cavernous sinus was detected by contrast-enhanced CT scanning of the brain. Interventions: He received intravenous injection of remdesivir with intravenous antibiotics (amoxicillin-A clavulanic 1.2 g/metronidazole 500 mg), and tocilizumab 400 mg intravenous once.He was also taken one unit of plasma transfusion with supportive care. Outcomes: After 1 week, the patient recovered from pneumonia and also recovered from features of cavernous sinus thrombosis. Lessons: COVID-19 infections are a serious cause of hypercoagulation condition which increases the chance of cavernous sinus thrombosis,which need early diagnosis and treatment.