游离三碘甲状腺原氨酸和游离甲状腺素水平与乳腺癌症风险的关系：一项荟萃分析。

IF 2 4区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endokrynologia Polska Pub Date : 2022-04-05 DOI:10.5603/EP.a2022.0020

Zheng-ming Lei, Bin Zeng, Lina Wu, Q. Deng, D. Guo

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引用次数: 0

摘要

乳腺癌(BC)和甲状腺激素(TH)之间的冲突已被研究多年。本研究的目的是总结和分析关于TH和BC之间关系的现有数据。材料与方法检索PubMed、EMBASE、Cochrane Library和b谷歌Scholar数据库以确定相关研究。采用固定效应或随机效应模型计算具有95%置信区间(CI)的平均差(MD)，以评估效应大小。结果13项符合条件的研究5957名受试者被纳入meta分析。本研究结果表明，BC与甲状腺激素存在显著的风险关系[游离三碘甲状腺原氨酸(FT3): MD = 1.01 pmol/L, 95% CI: 0.32-1.70，游离甲状腺素(FT4): MD = 0.26 ng/dL, 95% CI: 0.13-0.38]。结论与健康对照组相比，BC组FT3、FT4阳性风险较高。

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Free triiodothyronine and free thyroxine hormone levels in relation to breast cancer risk: a meta-analysis.

INTRODUCTION The conflict between breast cancer (BC) and thyroid hormone (TH) has been studied for years. The purpose of the study was to summarise and analyse the available data on the relationship between TH and BC. MATERIAL AND METHODS The PubMed, EMBASE, Cochrane Library, and Google Scholar databases were searched to identify relevant studies. The mean difference (MD) with 95% confidence interval (CI) were calculated by fixed or random effects models to assess the effect sizes. RESULTS Thirteen eligible studies with 5957 participants were included in the meta-analysis. The result of this study indicates that there is a significant risk relationship between BC and thyroid hormones [free triiodothyronine (FT3): MD = 1.01 pmol/L, 95% CI: 0.32-1.70, free thyroxine (FT4): MD = 0.26 ng/dL, 95% CI: 0.13-0.38]. CONCLUSIONS Compared with healthy controls, the positive risk of FT3 and FT4 is higher in BC.

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来源期刊

Endokrynologia Polska ENDOCRINOLOGY & METABOLISM-

CiteScore

2.60

自引率

9.50%

发文量

129

审稿时长

6-12 weeks

期刊介绍： "Endokrynologia Polska" publishes papers in English on all aspects of clinical and experimental endocrinology. The following types of papers may be submitted for publication: original articles, reviews, case reports, postgraduate education, letters to the Editor (Readers’ Forum) and announcements of scientific meetings, conferences and congresses.