精神分裂症认知障碍的遗传学研究进展

中华行为医学与脑科学杂志 Pub Date : 2020-01-20 DOI:10.3760/CMA.J.CN371468-20190515-00317

Yidan Ming, Shuzhan Gao, Jiayin Wang, J. Zhai, Xijia Xu

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引用次数: 0

摘要

精神分裂症是一种具有遗传背景的神经发育性脑疾病。认知障碍一直是精神分裂症的核心症状，遗传因素在精神分裂症认知障碍过程中起着重要作用。本文旨在探讨精神分裂症患者各种神经递质系统和神经发育相关基因与认知障碍的关系。以“精神分裂症”“认知”和“遗传”“多巴胺”“谷氨酸”“血清素”“去甲肾上腺素”“乙酰胆碱”“神经发育”“全基因组关联研究”为关键词，检索Pubmed、ScienceDirect、CNKI学术期刊数据库等多个数据库2001年1月至2019年10月发表的中英文文献，万方学术期刊数据库，并在大量阅读后选取符合综述主题的文献。同时，作者运用文献追踪的方法，对所查阅的文献进行了文献检索。最后，纳入29篇相关文献，发现精神分裂症的认知障碍与多种神经递质系统基因和神经发育基因有关，这些基因在认知障碍过程中有不同的作用机制。精神分裂症认知障碍的发生和发展涉及多种基因效应。神经递质系统和神经发育水平的遗传学研究有助于探索精神分裂症认知障碍的病理机制。未来的研究应重点关注精神分裂症的发病机制/候选基因如何影响神经递质系统和神经发育回路，并进一步阐明遗传因素在精神分裂症认知障碍发展中的机制。关键词：精神分裂症；认知功能障碍；遗传学

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Advances in the genetics of cognitive impairment in schizophrenia

Schizophrenia is a kind of neurodevelopmental brain disease with genetic background.Cognitive impairment has always been concerned as the core symptom of schizophrenia, and genetic factors play an important role in the cognitive impairment process of schizophrenia.This paper intends to explore the relationship between various neurotransmitter systems and neurodevelopmental related genes and cognitive impairment in schizophrenia. With " schizophrenia" " cognitive" and " genetic" " dopamine" " glutamate" " serotonin" " norepinephrine" " acetylcholine" " neurodevelopmental" " genome-wide association studies" as key words, the author searched the English and Chinese literatures published from January 2001 to October 2019 in several databases, such as Pubmed, ScienceDirect, CNKI academic journal database, Wanfang academic journal database, and selected the literature that was in line with the review topic after a large number of readings.Meanwhile, the author applied the literature tracing method to search the references of the literature that had been reviewed. Finally, 29 related literatures were included, and it was found that cognitive impairment in schizophrenia is related to multiple neurotransmitter system genes and neurodevelopmental genes, and these genes have different mechanisms of action in the process of cognitive impairment. The occurrence and development of cognitive impairment in schizophrenia involve multiple gene effects. The genetic study of neurotransmitter system and neurodevelopmental level is helpful to explore the pathological mechanism of cognitive impairment in schizophrenia.Future research should focus on how the pathogenesis/candidate genes of schizophrenia affect the neurotransmitter system and neurodevelopmental circuits, and further elucidate the mechanism of genetic factors in the development of cognitive impairment in schizophrenia. Key words: Schizophrenia; Cognitive dysfunction; Genetics

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来源期刊

中华行为医学与脑科学杂志

自引率

0.00%

发文量

8131

期刊介绍： "Chinese Journal of Behavioral Medicine and Brain Science" (CN 37-1468/R, ISSN 1674-6554) is a national academic journal under the supervision of the National Health Commission, sponsored by the Chinese Medical Association and Jining Medical College. The journal was founded in June 1992 and was formerly known as "Chinese Journal of Behavioral Medicine" (1992-1993) and "Chinese Behavioral Medical Science" (1994-2008). In 2009, it was renamed "Chinese Journal of Behavioral Medicine and Brain Science" with the approval of the State Administration of Press, Publication, Radio, Film and Television. The purpose of "Chinese Journal of Behavioral Medicine and Brain Science" is to implement the health and health policies of the Party and the State, implement the principle of combining theory with practice and popularization and improvement, and reflect the major progress in the theory and practical application of behavioral medicine and brain science in my country. It publishes academic papers and scientific research results in the field of behavioral medicine and brain science in my country, and has columns such as monographs/reviews, basic research, clinical research, health prevention, methods and techniques, psychological behavior and evaluation, and systematic evaluation.