STAT3信号在不同类型癌症中的作用:综述

Q4 Pharmacology, Toxicology and Pharmaceutics

Current Enzyme Inhibition Pub Date : 2020-11-04 DOI:10.2174/1573408016999200708160300

Kaviarasan Lakshmanan, Gowramma Byran, S. Bandlamudi, P. Krishnamurthy

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引用次数: 2

摘要

转录信号换能器和激活因子(STAT3)是一种重要的转录因子，能够通过超激活或获得功能突变介导甚至驱动癌症进展。它在调节宿主免疫和炎症反应以及许多癌症的发病机制中起着关键作用。然而，令人信服的证据表明，STAT3在许多癌症中被组成性激活，并在肿瘤生长和转移中起着至关重要的作用。HyperactiveSTAT3也与多种造血和实体恶性肿瘤有关，如慢性和急性髓性白血病、黑色素瘤或前列腺癌。对STAT功能的经典理解与它们磷酸化的平行二聚体构象有关，其中它们诱导基因转录。本文就STAT3信号在不同类型肿瘤中的功能和作用进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of STAT3 Signaling in Different Types of Cancers: A Comprehensive Review

Signal transducer and activator of transcription (STAT3) is an important transcription factor capable of mediating or even driving cancer progression through hyperactivation or gain-offunction mutations. It plays a key role in regulating host immune and inflammatory responses and in the pathogenesis of many cancers. However, compelling evidence suggests that STAT3 is constitutively activated in many cancers and plays a vital role in tumor growth and metastasis. Hyperactive STAT3 is also implicated in various hematopoietic and solid malignancies, such as chronic and acute myeloid leukemia, melanoma or prostate cancer. The classical understanding of STAT functions is linked to their phosphorylated parallel dimer conformation, in which they induce gene transcription. In this review, we discuss the functions and the roles of STAT3 signal in various types of cancers.

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来源期刊

Current Enzyme Inhibition Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

1.30

自引率

0.00%

发文量

期刊介绍： Current Enzyme Inhibition aims to publish all the latest and outstanding developments in enzyme inhibition studies with regards to the mechanisms of inhibitory processes of enzymes, recognition of active sites, and the discovery of agonists and antagonists, leading to the design and development of new drugs of significant therapeutic value. Each issue contains a series of timely, in-depth reviews written by leaders in the field, covering a range of enzymes that can be exploited for drug development. Current Enzyme Inhibition is an essential journal for every pharmaceutical and medicinal chemist who wishes to have up-to-date knowledge about each and every development in the study of enzyme inhibition.