蝙蝠红细胞表达核酸感应受体并结合RNA和DNA

Q3 Medicine
L. M. Lam, J. Dobkin, K. Eckart, Ian Gereg, A. DiSalvo, Amber Nolder, Eman Anis, J. Ellis, Greg Turner, N. Mangalmurti
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引用次数: 0

摘要

红细胞通过表达核酸传感器表现出免疫调节能力。然而,人们对蝙蝠红细胞知之甚少,也没有研究检测蝙蝠红细胞的免疫功能。在本研究中,我们发现蝙蝠红细胞表达核酸敏感TLRs TLR7和TLR9,并结合核酸配体、ssRNA和CpG DNA。总的来说,这些数据表明,像人类红细胞一样,蝙蝠红细胞具有免疫功能,可能是核酸的储存库。这些发现提供了对蝙蝠免疫的独特见解,并可能揭示人类致命病原体隐藏在蝙蝠体内的潜在机制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bat Red Blood Cells Express Nucleic Acid–Sensing Receptors and Bind RNA and DNA
RBCs demonstrate immunomodulatory capabilities through the expression of nucleic acid sensors. However, little is known about bat RBCs, and no studies have examined the immune function of bat erythrocytes. In this study, we show that bat RBCs express the nucleic acid–sensing TLRs TLR7 and TLR9 and bind the nucleic acid ligands, ssRNA, and CpG DNA. Collectively, these data suggest that, like human RBCs, bat erythrocytes possess immune function and may be reservoirs for nucleic acids. These findings provide unique insight into bat immunity and may uncover potential mechanisms by which virulent pathogens of humans are concealed in bats.
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来源期刊
CiteScore
3.70
自引率
0.00%
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4 weeks
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