早期生活经历对后代身高和寿命的跨代影响。18 -21世纪荷兰特塞尔岛族谱的探索性研究

IF 1 3区历史学 Q3 FAMILY STUDIES

History of the Family Pub Date : 2022-05-01 DOI:10.1080/1081602X.2022.2067579

J. Kok

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引用次数: 3

摘要

早期的生活经历会对几代人的健康产生持久的影响。由于涉及社会和生物因素的复杂相互作用，这些转基因传播的途径很难探索。这项研究通过控制共同的环境因素，探索了一种这样的途径——基因表达的遗传表观遗传修饰——的潜在作用。它使用了一个由荷兰特克斯岛六个谱系的后代家谱构建的数据库。2761名和3279名19岁男孩的身高和寿命分别与他们自己、父母和祖父母的早期生活经历有关。早期生活中的逆境是通过创伤和食物匮乏来研究的。逆境有明显的影响，尤其是对身高的影响，但这些影响很少会传递给子孙后代。

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Transgenerational effects of early-life experiences on descendants’ height and life span. An explorative study using Texel Island (Netherlands) genealogies, 18th-21st centuries

ABSTRACT Early-life experiences can have lasting effects on health across multiple generations. The pathways of these transgenerational transmissions are difficult to explore, because of the complex interactions of social and biological factors involved. This study explores the potential role of one such pathway – inherited epigenetic modifications to gene expression – by controlling for shared environmental factors. It uses a database constructed from descendant genealogies of six lineages from Texel Island, The Netherlands. Heights and life spans of respectively 2761 and 3279 19-year old boys are related to the early-life experiences of themselves, parents and grandparents. Adversity in early-life is studied through trauma and food deprivation. Adversity has clear effects, especially on heights, but few of these effects were transmitted to children and grandchildren.

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来源期刊

History of the Family Multiple-

CiteScore

2.10

自引率

10.00%

发文量

期刊介绍： The History of the Family: An International Quarterly makes a significant contribution by publishing works reflecting new developments in scholarship and by charting new directions in the historical study of the family. Further emphasizing the international developments in historical research on the family, the Quarterly encourages articles on comparative research across various cultures and societies in Asia, Africa, Latin America, and the Pacific Rim, in addition to Europe, the United States and Canada, as well as work in the context of global history.