性发育障碍:1例SRY (Y染色体性别决定区)基因阴性的杂交犬发生XX性反转

Clinical theriogenology Pub Date : 2022-06-01 DOI:10.58292/ct.v14.9287

Kelsey Martin, Agata M Parsons, Greg Burns, G. Bouma, Fiona K. Hollinshead

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引用次数: 0

摘要

一只8个月大的混血狗（来自收容所）被评估了其异常的外生殖器（从外阴向外突出的增大的阴蒂）状况。狗具有表型雌性外观。睾丸样组织通过腹腔镜辅助性腺切除术切除。使用血液和性腺组织（通过组织学和免疫组织化学）确定基因型。狗有XX条染色体，对SRY（Y染色体上的性别决定区）基因呈阴性。

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Disorders of sexual development: a case of XX sex reversal in a mixed breed dog negative for SRY (sex-determining region on the Y chromosome) gene

An 8-month mixed breed dog (from shelter) was evaluated for its abnormal external genital (enlarged os clitoris protruding externallyfrom the vulva) condition. Dog had phenotypic female appearance. Testicular-like tissue was removed via laparoscopy-assistedgonadectomy. Genotype was determined using blood and gonadal tissue (via histology and immunohistochemistry). Doghad XX chromosomes and was negative for SRY (sex-determining region on the Y chromosome) gene.

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Clinical theriogenology

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