(2-Benzyl-7) - 4-chlorophenyl 3-morpholino-6 - ((1-phenyl-1H-1 2 3-triazol-4-yl)甲基)6,7-dihydro-5H-pyrrolo pyridin-5-one(3、4 b)

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-07-10 DOI:10.3390/m1693

Perla Islas-Jácome, Cecilia García-Falcón, S. L. Castañón-Alonso, E. Calderon-jaimes, Daniel Canseco-González, A. Islas-Jácome, E. González-Zamora

引用次数: 0

摘要

由4-氯苯甲醛、（1-苯基-1H-1,2,3-三唑-4-基）甲胺、2-异氰基-1-吗啉-3-苯基丙-1-酮、，和马来酸酐，总产率为28%。通过1D（1H，13C）和2D（COSY，HSQC和HMBC）NMR、FT-IR和HRMS对合成的化合物进行了充分的表征。

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2-Benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one

The new polyheterocyclic compound, 2-benzyl-7-(4-chlorophenyl)-3-morpholino-6-((1-phenyl-1H-1,2,3-triazol-4-yl)methyl)-6,7-dihydro-5H-pyrrolo[3,4-b]pyridin-5-one, was synthesized by a sequential combination of 4-chlorobenzaldehyde, (1-phenyl-1H-1,2,3-triazol-4-yl)methanamine, 2-isocyano-1-morpholino-3-phenylpropan-1-one, and maleic anhydride under a microwave-assisted one-pot process [Ugi-Zhu/aza Diels-Alder cycloaddition/N-acylation/decarboxylation/dehydration] with a 28% overall yield. The synthesized compound was fully characterized by 1D (1H, 13C) and 2D (COSY, HSQC, and HMBC) NMR, FT-IR, and HRMS.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)