V. V. Bazarnyi, O. P. Kovtun, O. V. Koryakina, L. G. Polushina, A. Yu. Maksimova
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The Study of the Cerebrospinal Fluid Cytokine Profile in Children with Acute Lymphocytic Leukemia and Neurotoxic Side Effects of Chemotherapy
In some cases standard chemotherapy of acute lymphocytic leukemia (ALL) leads to neurotoxicity; its mechanisms, methods of prognosis, and prevention are being actively studied. The aim of this study was to assess the cerebrospinal fluid (CSF) cytokine profile in children with ALL and neurotoxic side effects of chemotherapy. This prospective study included 24 children with ALL aged from 3 to 17 years. Patients were further subdivided into ALL patients with (the main group) and without neurological complications (the comparison group). The level of CSF cytokines was measured by the Xmap technology (Luminex) using Invitrogen test systems (eBioscience) and the Luminex 200 system. The comparative analysis of the cytokine profile in the group of children with chemotherapy-induced neurotoxic complications revealed elevated levels of chemokine CXCL12 (SDF-1α) and stem cell factor (SCF). The increased level of these cytokines in CSF suggested a relatively risk for development of the toxic peripheral neuropathy.
期刊介绍：
Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.
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