一些表观遗传因子在DNA损伤反应途径中的作用

AIMS Genetics Pub Date : 2017-03-17 DOI:10.3934/genet.2017.1.69

Mrinalini Tiwari, S. Parvez, P. Agrawala

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引用次数: 4

摘要

摘要本文简要介绍了DNA损伤反应途径以及各种表观遗传学机制在DNA损伤反应通路中的作用。主要关注的是导致染色质结构改变的组蛋白修饰，因为紧密的染色质结构对DNA修复过程构成了主要限制。基于这一假设，我们的实验室还评估了某些组蛋白脱乙酰酶抑制剂作为潜在的放射性缓解剂，并在综述结束时对其进行了简要讨论。

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Role of some epigenetic factors in DNA damage response pathway

Abstract The current review gives a brief account of the DNA damage response pathway and involvement of various epigenetic mechanisms in DNA damage response pathway. The main focus is on histone modifications leading to structural alterations in chromatin since the compact chromatin structure poses a major limitation in the DNA repair process. Based on this hypothesis, our laboratory has also evaluated certain histone deacetylase inhibitors as potential radiomitigators and the same has been discussed in brief at the end of the review.

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来源期刊

AIMS Genetics GENETICS & HEREDITY-

自引率

0.00%

发文量

审稿时长

12 weeks