病原微生物核酸检测的研究进展。(特刊:生物安全材料)

应用化学 Pub Date : 2021-05-01 DOI:10.19894/J.ISSN.1000-0518.210099

Liu Zi-yue, Yang Tong-Ren, Y. Ge, Huang Yuanyu

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引用次数: 0

摘要

2019年12月，2019冠状病毒病(COVID-19)在全球爆发，使生物安全成为全球具有吸引力和关键的发展方向。病原微生物的快速、准确、低成本检测是保证生物安全的重要问题之一，是疫情防控和诊断的关键。本文详细介绍了基于核酸测序、等温扩增和基因编辑(CRISPR/Cas)技术的生物传感器在集成便携式设备中的应用。这些技术的发展为开发低成本、高效率和结果可视化的综合检测方法提供了可能。有望为有效防治病原微生物提供技术保障。

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Research progresses of nucleic acid based detection of pathogenic microorganisms. (Special Issue: Biosafety materials.) [Chinese]

In December 2019, the global outbreak of Corona Virus Disease 2019 (COVID-19)made biosafety an attractive and crucial development direction globally. Rapid, accurate and low-cost detection of pathogenic microorganisms is one of the important issue to ensure biosafety, and is the key to epidemic prevention, control and diagnosis. This review elaborately introduces the applications of biosensors based on nucleic acid sequencing, isothermal amplification and gene editing (CRISPR/Cas) in integrated portable devices. The development of these technologies offers the possibility of developing low-cost, high-efficiency and result-visualization integrated detection methods. It is expected to provide technology guarantees for the effective prevention and control of pathogenic microorganisms.

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来源期刊

应用化学化学

CiteScore

0.90

自引率

0.00%

发文量

9102

期刊介绍： Founded in 1983, Chinese Journal of Applied Chemistry is a comprehensive academic journal published and distributed worldwide by the Science Press. The journal, governed by the Chinese Academy of Sciences (CAS), is sponsored by the Chinese Chemical Society (CCS) and the Changchun Institute of Applied Chemistry (CIAC). The journal mainly reports on innovative basic research and creative scientific results in chemistry and inter-disciplines. It is published on the 10th day of each month and delivers approximately 1400 pages each year of research articles and reviews on cutting-edge areas in chemistry, including organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, polymer chemistry, materials science, life science, and information science. Chinese Journal of Applied Chemistry is a peer-reviewed and open access journal consisting of Reviews, Research Articles and Communications. Articles published in the journal are included in 11 domestic and international databases. The Readership include Chemists in research institutes, colleges, universities, and relevant industries.