膜活性线粒体靶向抗肿瘤药物和给药系统

IF 1.1 Q4 CELL BIOLOGY

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology Pub Date : 2023-08-14 DOI:10.1134/S1990747823040062

A. P. Sadikov, Z. G. Denieva, U. A. Budanova, Yu. L. Sebyakin

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引用次数: 0

摘要

线粒体是细胞的“发电站”。没有它们，活细胞的正常功能是不可能的。由于线粒体参与的多种过程以及健康细胞和肿瘤细胞中线粒体之间的差异，这种细胞器是抗肿瘤治疗的一个有吸引力的靶点。在这篇综述中，各种方法的发展诊断和治疗药物选择性地针对肿瘤细胞的线粒体进行了描述。描述了主要的线粒体载体配体，以及它们与已知抗肿瘤药物的结合以及与常见药物传递系统的结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Membrane-Active Mitochondria-Targeted Antitumor Agents and Drug Delivery Systems

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Membrane-Active Mitochondria-Targeted Antitumor Agents and Drug Delivery Systems

Abstract—

Mitochondria are the “power stations” of cells. Without them, the normal functioning of a living cell is impossible. This organelle is an attractive target for antitumor therapy because of the variety of processes in which mitochondria are involved and the differences between mitochondria in healthy and tumor cells. In this review, various approaches to the development of diagnostic and therapeutic agents selectively directed to the mitochondria of tumor cells are described. The main mitochondrial vector ligands are described, as well as their conjugation with known antitumor drugs and combination with common drug delivery systems.

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来源期刊

Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology CELL BIOLOGY-

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology is an international peer reviewed journal that publishes original articles on physical, chemical, and molecular mechanisms that underlie basic properties of biological membranes and mediate membrane-related cellular functions. The primary topics of the journal are membrane structure, mechanisms of membrane transport, bioenergetics and photobiology, intracellular signaling as well as membrane aspects of cell biology, immunology, and medicine. The journal is multidisciplinary and gives preference to those articles that employ a variety of experimental approaches, basically in biophysics but also in biochemistry, cytology, and molecular biology. The journal publishes articles that strive for unveiling membrane and cellular functions through innovative theoretical models and computer simulations.