树枝状聚合物在药物溶解中的作用——综述

Q2 Pharmacology, Toxicology and Pharmaceutics

Drug Delivery Letters Pub Date : 2019-11-30 DOI:10.2174/2210303109666190319165209

Ravi Patel

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引用次数: 2

摘要

树状大分子是一类新的合成聚合物，由于其独特的特性，包括水溶性、均匀的大小和形状、确定的分子量、多价性、生物相容性和内腔，被证明是生物医学应用的非常有用的工具。药物分子的疏水性给有效剂型的开发带来了障碍，并导致药物递送不足。增强溶解度是树状大分子的关键性质之一。疏水药物分子通过络合作用被包裹在树状大分子的空腔中，并在水溶液中溶解。本文介绍了树突状分子及其在生物医学上的应用，如原料药的溶解度。详细介绍了树状大分子及其在药物溶解度中的应用的不同研究文章、研究论文、评论和专利的年度调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of Dendrimer in Drug Solubilisation - A Review

Dendrimers, a new class of synthetic polymers proved themselves very useful tools for biomedical application due to their unique characteristics including water solubility, uniform size and shape, defined molecular weight, multivalency, biological compatibility and internal cavities. The hydrophobicity of a drug molecule creates hurdles in the development of effective dosage form and presents insufficient drug delivery to the target site. Solubility enhancement is one of the key properties of a dendrimer. The hydrophobic drug molecules are entrapped in the cavities of a dendrimer by complexation and get solubilized in the aqueous solution. The present article contains information on dendrimer and its biomedical application such as API solubility. The detailed study presents year wise survey of different research articles, research papers, reviews and patents on dendrimer and its application in drug solubility.

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来源期刊

Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.70

自引率

0.00%

发文量