染料木素-分子特征、与雌二醇的相似性和药理潜力

IF 0.4 4区 医学 Q4 PHARMACOLOGY & PHARMACY
Kacper Kossakowski, A. Pawełczyk, L. Zaprutko
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引用次数: 0

摘要

近年来,科学界对染料木素越来越感兴趣。由于其在治疗各种疾病和作为功能性食品方面的潜力,它一直是广泛研究的主题。染料木黄酮的医学益处在文献中有很好的记载。已经进行了几项研究,以更好地了解其对健康的受益作用机制,并改善其药代动力学和药效学参数。它已被批准用于缓解更年期症状,并因其用于治疗炎症和年龄相关疾病、癌症、代谢疾病、遗传疾病和皮肤护理而受到关注。染料木素与内源性雌二醇表现出相当大的相似性。它被归类为植物雌激素,表现出与人体雌激素相对应的特性。由染料木素和雌二醇分子外观的上述相似性产生的雌激素活性使染料木素有可能同时作为雌激素激动剂和拮抗剂,这取决于发现染料木素的环境中存在的内源性激素的数量和组织类型。分析了染料木素和雌二醇化学结构的相似性,雌二醇和染料木素之间的相互作用以及雌激素受体的氨基酸结合位点。需要进一步的对照试验来确定染料木素的疗效和安全性。未来的研究将侧重于通过结构修饰和创新的给药方法提高其生物利用度,并进行人体试验以确认其生物和药理作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Genistein - characterization of the molecule, similarity to estradiol and pharmacological potential
In recent years, the scientific world has become more interested in genistein. It has been the subject of extensive research for its potential in treating various diseases and as a functional food. The medical benefits of genistein are well documented in the literature. Several studies have been performed to better understand the mechanisms of its beneficiary effects on health and to improve its pharmacokinetic and pharmacodynamic parameters. It has been approved for relieving menopausal symptoms and has received attention for its use in the treatment of inflammatory and age-related disorders, cancer, metabolic illnesses, genetic disorders, and skin care. Genistein shows considerable similarity to endogenous estradiol. It is classified in the group known as phytoestrogens which exhibit properties corresponding to estrogen in the human body. The estrogenic activity resulting from the aforementioned similarity in the appearance of genistein and estradiol molecules makes it possible for genistein to act as both an estrogen agonist and antagonist, depending on the number of endogenous hormones present in the environment in which it is found and the type of tissue. The similarity of the chemical structure of genistein and estradiol and interactions occurring between estradiol and genistein and the amino acid binding site of the estrogen receptors were analyzed. Further controlled trials are needed to determine the efficacy and safety of genistein. Future research will focus on enhancing its bioavailability through structural modification and innovative delivery methods and conducting human trials to confirm its biological and pharmacological effects.
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
74
审稿时长
6-12 weeks
期刊介绍: The international journal of the Polish Pharmaceutical Society is published in 6 issues a year. The journal offers Open Access publication of original research papers, short communications and reviews written in English, in all areas of pharmaceutical sciences. The following areas of pharmaceutical sciences are covered: Analysis, Biopharmacy, Drug Biochemistry, Drug Synthesis, Natural Drugs, Pharmaceutical Technology, Pharmacology and General. A bimonthly appearing in English since 1994, which continues “Acta Poloniae Pharmaceutica”, whose first issue appeared in December 1937. The war halted the activity of the journal’s creators. Issuance of “Acta Poloniae Pharmaceutica” was resumed in 1947. From 1947 the journal appeared irregularly, initially as a quarterly, then a bimonthly. In the years 1963 – 1973 alongside the Polish version appeared the English edition of the journal. Starting from 1974 only works in English are published in the journal. Since 1995 the journal has been appearing very regularly in two-month intervals (six books a year). The journal publishes original works from all fields of pharmacy, summaries of postdoctoral dissertations and laboratory notes.
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