纳米生物材料在抗病毒疫苗佐剂中的应用

应用化学 Pub Date : 2021-05-01 DOI:10.19894/j.issn.1000-0518.210062

L. Cao, Z. Wang, B. Wang

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引用次数: 3

摘要

病毒性传染病严重危害人类健康，新型冠状肺炎已成为全球性重大公共安全卫生事件。疫苗接种是有效预防和控制病毒感染和传染病传播的重要途径。常规疫苗存在半衰期短、免疫原性弱、靶向性弱、吸收慢、储存和运送要求高等不足。近年来，纳米生物材料因其较低的系统毒性、较强的组织靶向性、较高的比表面积和较低的免疫滴度，有望作为疫苗佐剂用于病毒性传染病的预防和治疗。本文就纳米生物材料作为抗病毒疫苗佐剂的分类、作用途径和机制作一综述。此外，结合目前全球流行的冠状病毒病-19 (COVID-19)，介绍了纳米生物材料在新冠疫苗中的应用。最后，总结了纳米生物材料在抗病毒疫苗佐剂中面临的挑战。©2021，中国科学出版社版权所有。

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Application of nano biomaterials in antiviral vaccine adjuvant

Viral infectious diseases seriously endanger human health, the new type of coronary pneumonia has become a major global public safety and health incident. Vaccination is an important way to effectively prevent and control viral infections and the spread of infectious diseases. While routine vaccines have shown a shortfall, such as short half-life, weak immunogenicity, weak targeting, slow absorption, and high storage and delivery requirements. In recent years, nanobiomaterials are expected to be used as vaccine adjuvants for the prevention and treatment of viral infectious diseases due to their lower systemic toxicity, stronger tissue targeting, higher specific surface area and lower immune titer. This review will focus on the classification, action pathways and mechanisms of nanobiomaterials as adjuvants for antiviral vaccines. In addition, the application of nanobiomaterials in the new crown vaccine is described in combination with coronavirus disease-19 (COVID-19), which is currently popular worldwide. Finally, the challenges faced by nanobiomaterials in antiviral vaccine adjuvants are summarized. © 2021, Science in China Press. All rights reserved.

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来源期刊

应用化学化学

CiteScore

0.90

自引率

0.00%

发文量

9102

期刊介绍： Founded in 1983, Chinese Journal of Applied Chemistry is a comprehensive academic journal published and distributed worldwide by the Science Press. The journal, governed by the Chinese Academy of Sciences (CAS), is sponsored by the Chinese Chemical Society (CCS) and the Changchun Institute of Applied Chemistry (CIAC). The journal mainly reports on innovative basic research and creative scientific results in chemistry and inter-disciplines. It is published on the 10th day of each month and delivers approximately 1400 pages each year of research articles and reviews on cutting-edge areas in chemistry, including organic chemistry, inorganic chemistry, physical chemistry, analytical chemistry, polymer chemistry, materials science, life science, and information science. Chinese Journal of Applied Chemistry is a peer-reviewed and open access journal consisting of Reviews, Research Articles and Communications. Articles published in the journal are included in 11 domestic and international databases. The Readership include Chemists in research institutes, colleges, universities, and relevant industries.