In Vitro Comparison of Different Brands of Cetirizine 2HCl Tablets by Spectroscopy and Thin Layer Chromatography (TLC) in Local Market of Lahore, Pakistan

The objective of the present study is to investigate and compare the efficacy, physiochemical equivalence and purity of API’s of different brands of cetirizine 2HCl tablets (10mg) with that of multinational brands available in local market of Lahore, Pakistan. The present work also provides awareness to allergy patients about most effective local brands with reasonable prices, without any health risk. Spectrophotometric method is used for chemical assay, TLC technique is subjected for the purity of API’s and physiochemical parameters is employed i.e. weight variation, hardness, friability, thickness, disintegration time and dissolution study as well as price fluctuation in PK rupees. The results of all physiochemical parameters and chemical assay are found to be within limit and meet to the pharmacopeial standards. TLC technique is developed to check the quality and purity of API, all the active ingredients showed the similar Rf -values without any impurity (0.38-0.39). From the test results and plots, it is observed and concluded that an economical and quality products can be prescribed for allergy patients whether they are manufactured by the local or multinational pharmaceutical companies without any health risk.