Erastin在铁下垂中的作用

Q4 Medicine

肿瘤研究与临床 Pub Date : 2019-11-28 DOI:10.3760/CMA.J.ISSN.1006-9801.2019.11.017

Yuechen Zhao, Lili Zhong, Yinlong Zhao

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引用次数: 2

摘要

脱铁症是近年来新发现的一种细胞死亡形式。其本质是细胞内脂质活性氧（L-ROS）以铁依赖的方式积累引起的细胞过氧化死亡。Erastin作为一种高效的脱铁诱导剂，通过胱氨酸谷氨酸转运受体、电压依赖性阴离子通道和p53等多种分子介导脱铁。更重要的是，Erastin可以增强癌症细胞对化疗和放疗的敏感性，因此可以作为一种新型抗癌药物。本文综述了Erastin的发现、脱铁途径、Erastin诱导脱铁的途径、Erastin的抗肿瘤特性以及国内外最新研究成果。关键词：细胞死亡；抗肿瘤联合化疗方案；Erastin；铁下垂

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The role of Erastin in ferroptosis

Ferroptosis is a newly discovered form of cell death in recent years. Its essence is the cell peroxidation death caused by the accumulation of intracellular lipid reactive oxygen species (L-ROS) in a iron-dependent manner. As a highly efficient ferroptosis inducer, Erastin mediates ferroptosis through multiple molecules, such as cystine-glutamate transport receptor, voltage-dependent anion channel and p53. More importantly, Erastin can enhance the sensitivity of cancer cells to chemotherapy and radiotherapy, so it can be used as a new type of anticancer drug. This article reviews the discovery of Erastin, the pathways of ferroptosis, the pathways of Erastin-induced ferroptosis, the anti-tumor characteristics of Erastin, and the latest domestic and international research results. Key words: Cell death; Antineoplastic combined chemotherapy protocols; Erastin; Ferroptosis

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.