卵蛋白精油的抗真菌活性。抗糠皮马拉色菌和念珠菌

IF 0.7 Q4 CHEMISTRY, MULTIDISCIPLINARY
Gardênia Barbosa Carrijo Rodrigues, C. Fernandes, S. M. L. O. Marcionilio, Vitor de Paula Castro, Carmen Magaly Alvarez, R. H. Pires, M. B. Santiago, R. Pedroso, C. Martins, M. Miranda
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引用次数: 0

摘要

近几十年来,由于免疫抑制患者的增加和抗真菌药物的滥用,真菌机会性感染有所增加。巴西是世界上生物多样性最强的国家,从自然资源中寻找新的抗真菌药物的研究受到了刺激。Protium ovatum Engl。,属于Burseraceae科,是一种灌木树,主要分布在巴西的塞拉多生物群落中,具有药用、食用和芳香用途。本研究旨在研究卵蛋白成熟果实(RF-EO)和未成熟果实(UF-EO)中精油的化学成分、抗糠皮马拉色菌和抗癌活性。采用微量稀释液法测定EOs的抗真菌活性。GC-FID和GC-MS分析表明,柠檬烯、α-蒎烯和月桂烯是两种EOs的主要成分。RF-EO和UF-EO对毛霉菌的MIC值分别为375和1500µg/mL。RF-EO的MIC值在62.5至250µg/mL之间,而UF-EO对念珠菌属有轻微活性(>1000µg/mL)。此外,RF-EO对念珠菌具有抗菌膜活性,对秀丽隐杆线虫幼虫无毒。这项研究表明,卵形假单胞菌的EOs可能是由毛皮分枝杆菌和念珠菌引起的传染病的替代治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antifungal Activities of Essential Oils from Protium ovatum Engl. Against Malassezia furfur and Candida Species
Fungal opportunistic infections have increased in recent decades due to the increase in the immunosuppressed patients and the indiscriminate use of antifungals. In Brazil, a country with the greatest biodiversity in the world, studies that seek new antifungals from natural sources have been stimulated. Protium ovatum Engl., belongs to the Burseraceae family and is a shrub tree found mainly in Brazil, in the Cerrado biome, and has medicinal, food and aromatic uses. This study aims to investigate the chemical composition and the anti-Malassezia furfur and anticandidal activities of essential oils (EOs) from Protium ovatum ripe fruit (RF-EO) and unripe fruit (UF-EO). The EOs antifungal activities were determined by microdilution broth methodology. GC-FID and GC-MS analyses showed that limonene, α-pinene and myrcene were the major components of both EOs. MIC values of RF-EO and UF-EO against M. furfur were 375 and 1500 µg/mL, respectively. RF-EO exhibited MIC values between 62.5 and 250 µg/mL while UF-EO was slightly active (> 1000 µg/mL) against Candida species. In addition, RF-EO showed antibiofilm activity against Candida species and was not toxic to C. elegans larvae. This study suggests that EOs from P. ovatum could be an alternative therapeutic option for infectious diseases caused by M. furfur and Candida species.
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来源期刊
Orbital: The Electronic Journal of Chemistry
Orbital: The Electronic Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
1.10
自引率
0.00%
发文量
25
审稿时长
10 weeks
期刊介绍: Orbital: The Electronic Journal of Chemistry is a quarterly scientific journal published by the Institute of Chemistry of the Universidade Federal de Mato Grosso do Sul, Brazil. Original contributions (in English) are welcome, which focus on all areas of Chemistry and their interfaces with Pharmacy, Biology, and Physics. Neither authors nor readers have to pay fees. The journal has an editorial team of scientists drawn from regions throughout Brazil and world, ensuring high standards for the texts published. The following categories are available for contributions: 1. Full papers 2. Reviews 3. Papers on Education 4. History of Chemistry 5. Short communications 6. Technical notes 7. Letters to the Editor The Orbital journal also publishes a number of special issues in addition to the regular ones. The central objectives of Orbital are threefold: (i) to provide the general scientific community (at regional, Brazilian, and worldwide levels) with a formal channel for the communication and dissemination of the Chemistry-related literature output by publishing original papers based on solid research and by reporting contributions which further knowledge in the field; (ii) to provide the community with open, free access to the full content of the journal, and (iii) to constitute a valuable channel for the dissemination of Chemistry-related investigations.
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